Applicability of a monoclonal antibody-based dipstick in diagnosis of urinary schistosomiasis in the Central Region of Ghana
dc.contributor.author | Bosompem, K.M. | |
dc.contributor.author | Owusu, O. | |
dc.contributor.author | Okanla, E.O. | |
dc.contributor.author | Kojima, S. | |
dc.date.accessioned | 2019-03-14T14:02:31Z | |
dc.date.available | 2019-03-14T14:02:31Z | |
dc.date.issued | 2004-09 | |
dc.description.abstract | We tested a rapid visually read monoclonal antibody (MoAb) based dipstick assay for specific diagnosis of urinary schistosomiasis against microscopy and the use of haematuria and proteinuria in a schistosomiasis haematobia endemic area in the Central Region of Ghana. The study group consisted of 141 school children (83 males, 58 females) aged 8-19 years. A total of 129 of 141 (91.5%) submitted stool samples, and 7.8% had Schistosoma mansoni, 55% had hookworms and 6.2% had tapeworms. The presence of S. mansoni and intestinal parasites did not appear to influence the results of the MoAb-dipstick assay. The urinary schistosomiasis prevalence by MoAb-dipstick (78%) was higher (P < 0.05) than the estimate by microscopy (60.3%), microhaematuria (27%) and proteinuria (30.5%). The MoAb-dipstick correctly identified 98.8% of microscopically confirmed cases and missed one (1.3%). The dipstick was also positive for 26 of 56 (46.4%) egg-negative individuals, thereby giving a sensitivity of 98.8% and a specificity of 53.6%. On the other hand, microhaematuria and proteinuria were 38.8% and 30.6% sensitive, and 91.1% and 69.6% specific, respectively. Microhaematuria and proteinuria were less sensitive (P < 0.05) than both microscopy and MoAb-dipstick. | en_US |
dc.identifier.other | Volume 9, Issue 9, Pages 991-996 | |
dc.identifier.other | https://doi.org/10.1111/j.1365-3156.2004.01289.x | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/28638 | |
dc.language.iso | en | en_US |
dc.publisher | Tropical Medicine and International Health | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Dipstick | en_US |
dc.subject | Monoclonal antibody | en_US |
dc.subject | Urinary schistosomiasis | en_US |
dc.title | Applicability of a monoclonal antibody-based dipstick in diagnosis of urinary schistosomiasis in the Central Region of Ghana | en_US |
dc.type | Article | en_US |
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