N-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amide
dc.contributor.author | Okine, L.K. | |
dc.contributor.author | Dofuor, A.K. | |
dc.contributor.author | Kwain, S. | |
dc.contributor.author | Osei, E. | |
dc.contributor.author | Tetevi, G.M. | |
dc.contributor.author | Ohashi, M. | |
dc.contributor.author | Gwira, T.M. | |
dc.contributor.author | Kyeremeh, K. | |
dc.date.accessioned | 2019-09-27T09:32:23Z | |
dc.date.available | 2019-09-27T09:32:23Z | |
dc.date.issued | 2019-07-03 | |
dc.description | Research Article | en_US |
dc.description.abstract | Abstract: The plant Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler is one of the most important medicinal species of the genus Zanthoxylum on the African continent. It is used in the treatment and management of parasitic diseases in sub-Saharan Africa. These properties have inspired scientists to investigate species within the genus for bioactive compounds. However, a study, which details a spectroscopic, spectrometric and bioactivity guided extraction and isolation of antiparasitic compounds from the genus Zanthoxylum is currently non-existent. Tortozanthoxylamide (1), which is a derivative of the known compound armatamide was isolated from Z. zanthoxyloides and the full structure determined using UV, IR, 1D/2D-NMR and high-resolution liquid chromatography tandem mass spectrometry (HRESI-LC-MS) data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for animal African trypanosomiasis in sub-Saharan Africa, 1 (IC50 7.78 M) was just four times less active than the commercially available drug diminazene aceturate (IC50 1.88 M). Diminazene aceturate is a potent drug for the treatment of animal African trypanosomiasis. Tortozanthoxylamide (1) exhibits a significant antitrypanosomal activity through remarkable alteration of the cell cycle in T. brucei subsp. brucei, but it is selectively non-toxic to mouse macrophages RAW 264.7 cell lines. This suggests that 1 may be considered as a sca old for the further development of natural antitrypanosomal compounds. | en_US |
dc.description.sponsorship | World Bank African Centres of Excellence grant (ACE02-WACCBIP: Awandare) and a DELTAS Africa grant (DEL-15-007: Awandare)New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from theWellcome Trust (107755/Z/15/Z: Awandare) and the UK government.University of Ghana,TWAS Research Grant Award,Cambridge-Africa Partnership for Research Excellence (CAPREx,Cambridge-Africa ALBORADA Research Fund for support and MRC African Research Leaders MR/S00520X/1 Award | en_US |
dc.identifier.other | doi:10.3390/M1070 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/32318 | |
dc.language.iso | en | en_US |
dc.publisher | Molbank | en_US |
dc.relation.ispartofseries | 3;2019 | |
dc.subject | Trypanosomiasis | en_US |
dc.subject | Antitrypanosomals | en_US |
dc.subject | Cell cycle | en_US |
dc.subject | Cell viability | en_US |
dc.subject | Zanthoxylum | en_US |
dc.subject | Rutaceae | en_US |
dc.subject | 1,3-benzodioxole | en_US |
dc.subject | Spectroscopy | en_US |
dc.title | N-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amide | en_US |
dc.type | Article | en_US |
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