N-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amide

Simple item page
dc.contributor.authorOkine, L.K.
dc.contributor.authorDofuor, A.K.
dc.contributor.authorKwain, S.
dc.contributor.authorOsei, E.
dc.contributor.authorTetevi, G.M.
dc.contributor.authorOhashi, M.
dc.contributor.authorGwira, T.M.
dc.contributor.authorKyeremeh, K.
dc.date.accessioned2019-09-27T09:32:23Z
dc.date.available2019-09-27T09:32:23Z
dc.date.issued2019-07-03
dc.descriptionResearch Articleen_US
dc.description.abstractAbstract: The plant Zanthoxylum zanthoxyloides (Lam.) Zepern. & Timler is one of the most important medicinal species of the genus Zanthoxylum on the African continent. It is used in the treatment and management of parasitic diseases in sub-Saharan Africa. These properties have inspired scientists to investigate species within the genus for bioactive compounds. However, a study, which details a spectroscopic, spectrometric and bioactivity guided extraction and isolation of antiparasitic compounds from the genus Zanthoxylum is currently non-existent. Tortozanthoxylamide (1), which is a derivative of the known compound armatamide was isolated from Z. zanthoxyloides and the full structure determined using UV, IR, 1D/2D-NMR and high-resolution liquid chromatography tandem mass spectrometry (HRESI-LC-MS) data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for animal African trypanosomiasis in sub-Saharan Africa, 1 (IC50 7.78 M) was just four times less active than the commercially available drug diminazene aceturate (IC50 1.88 M). Diminazene aceturate is a potent drug for the treatment of animal African trypanosomiasis. Tortozanthoxylamide (1) exhibits a significant antitrypanosomal activity through remarkable alteration of the cell cycle in T. brucei subsp. brucei, but it is selectively non-toxic to mouse macrophages RAW 264.7 cell lines. This suggests that 1 may be considered as a sca old for the further development of natural antitrypanosomal compounds.en_US
dc.description.sponsorshipWorld Bank African Centres of Excellence grant (ACE02-WACCBIP: Awandare) and a DELTAS Africa grant (DEL-15-007: Awandare)New Partnership for Africa’s Development Planning and Coordinating Agency (NEPAD Agency) with funding from theWellcome Trust (107755/Z/15/Z: Awandare) and the UK government.University of Ghana,TWAS Research Grant Award,Cambridge-Africa Partnership for Research Excellence (CAPREx,Cambridge-Africa ALBORADA Research Fund for support and MRC African Research Leaders MR/S00520X/1 Awarden_US
dc.identifier.otherdoi:10.3390/M1070
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/32318
dc.language.isoenen_US
dc.publisherMolbanken_US
dc.relation.ispartofseries3;2019
dc.subjectTrypanosomiasisen_US
dc.subjectAntitrypanosomalsen_US
dc.subjectCell cycleen_US
dc.subjectCell viabilityen_US
dc.subjectZanthoxylumen_US
dc.subjectRutaceaeen_US
dc.subject1,3-benzodioxoleen_US
dc.subjectSpectroscopyen_US
dc.titleN-(Isobutyl)-3,4-methylenedioxy Cinnamoyl Amideen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nisobutyl34methylenedioxy-cinnamoyl-amideMolBank.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

West African Centre for Cell Biology of Infectious Pathogens