Characterization of Chitosan/ Zeolite drug delivery composite and curcumin release kinetics in a simulated pH environment
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Scientific African
Abstract
Cancer remains a formidable global health challenge, necessitating innovative strategies for
effective drug delivery to tumor sites. This study is focused on modeling the release profile of a
chitosan/zeolite nanocomposite beads delivery system encapsulating curcumin. The nano composites were synthesized by functionalizing zeolite with chitosan and subsequently loading
curcumin. The chitosan/zeolite nanocomposite was characterized for its physicochemical prop erties, including surface morphology, functional groups, elemental profile, crystal structure, and
drug loading capacity using SEM, FTIR, EDS, XRD, and UV–vis spectrophotometer respectively. In
vitro experiments investigated the release kinetics of curcumin from the composite in simulated
pH environments, providing insights into the drug release behavior. The chitosan/zeolite nano composite demonstrated a controlled, and sustained release of curcumin, exhibiting significant
potential for optimizing therapeutic outcomes. The maximum entrapment efficiency of the chi tosan/zeolite drug delivery vehicle was recorded at 84 %, indicating high efficiency in encap sulating drug molecules. Drug release kinetics were analysed using the Higuchi, Korsmeyer
Peppas, Zero-Order, First-Order, and Hixson-Crowell models. The Higuchi kinetic model, which
explains the release rate of drugs from an insoluble matrix based on Fickian diffusion, best
explained the release of curcumin, with a correlation coefficient of R2 = 0.9351. These results
indicate that the zeolite functionalized chitosan nanocomposite beads hold promise as a viable
platform for enhanced drug delivery, enabling prolonged drug circulation and improved thera
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Research Article