Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents

dc.contributor.authorZeller, M.
dc.contributor.authorHeylen, E.
dc.contributor.authorDamanka, S.
dc.contributor.authorPietsch, C.
dc.contributor.authorDonato, C.
dc.contributor.authorTamura, T.
dc.contributor.authorKulkarni, R.
dc.contributor.authorArora, R.
dc.contributor.authorCunliffe, N.
dc.contributor.authorMaunula, L.
dc.contributor.authorPotgieter, C.
dc.contributor.authorTamim, S.
dc.contributor.authorDe Coster, S.
dc.contributor.authorZhirakovskaya, E.
dc.contributor.authorBdour, S.
dc.contributor.authorO'Shea, H.
dc.contributor.authorKirkwood, C.D.
dc.contributor.authorSeheri, M.
dc.contributor.authorNyaga, M.M.
dc.contributor.authorMphahlele, J.
dc.contributor.authorChitambar, S.D.
dc.contributor.authorDagan, R.
dc.contributor.authorArmah, G.
dc.contributor.authorTikunova, N.
dc.contributor.authorVan Ranst, M.
dc.contributor.authorMatthijnssens, J.
dc.date.accessioned2018-09-13T09:54:13Z
dc.date.available2018-09-13T09:54:13Z
dc.date.issued2015-08
dc.description.abstractThe majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-)complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988–2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The time to the most recent common ancestor (TMRCA) of all OP354-like P[8] genes was estimated at 1987. However, most OP354-like P[8] strains were found in three main clusters with TMRCAs estimated between 1996 and 2001. The VP7 gene segment of OP354-like P[8] strains showed evidence of frequent reassortment, even in localized epidemics, suggesting that OP354like P[8] genes behave in a similar manner on the evolutionary level as other P[8] subtypes. The results of this study suggest that OP354-like P[8] strains have been able to disperse globally in a relatively short time period. This, in combination with a relatively large genetic distance to other P[8] subtypes, might result in a lower vaccine effectiveness, underscoring the need for a continued surveillance of OP354-like P[8] strains, especially in countries where rotavirus vaccination programs are in place.en_US
dc.identifier.otherdoi: 10.1093/molbev/msv088
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/24120
dc.language.isoenen_US
dc.publisherMolecular Biology and Evolutionen_US
dc.subjectOP354-like P[8]en_US
dc.subjectrotavirusesen_US
dc.subjectemerging virusesen_US
dc.subjectreassortmenten_US
dc.titleEmerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continentsen_US
dc.typeArticleen_US

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