Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents
dc.contributor.author | Zeller, M. | |
dc.contributor.author | Heylen, E. | |
dc.contributor.author | Damanka, S. | |
dc.contributor.author | Pietsch, C. | |
dc.contributor.author | Donato, C. | |
dc.contributor.author | Tamura, T. | |
dc.contributor.author | Kulkarni, R. | |
dc.contributor.author | Arora, R. | |
dc.contributor.author | Cunliffe, N. | |
dc.contributor.author | Maunula, L. | |
dc.contributor.author | Potgieter, C. | |
dc.contributor.author | Tamim, S. | |
dc.contributor.author | De Coster, S. | |
dc.contributor.author | Zhirakovskaya, E. | |
dc.contributor.author | Bdour, S. | |
dc.contributor.author | O'Shea, H. | |
dc.contributor.author | Kirkwood, C.D. | |
dc.contributor.author | Seheri, M. | |
dc.contributor.author | Nyaga, M.M. | |
dc.contributor.author | Mphahlele, J. | |
dc.contributor.author | Chitambar, S.D. | |
dc.contributor.author | Dagan, R. | |
dc.contributor.author | Armah, G. | |
dc.contributor.author | Tikunova, N. | |
dc.contributor.author | Van Ranst, M. | |
dc.contributor.author | Matthijnssens, J. | |
dc.date.accessioned | 2018-09-13T09:54:13Z | |
dc.date.available | 2018-09-13T09:54:13Z | |
dc.date.issued | 2015-08 | |
dc.description.abstract | The majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-)complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988–2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The time to the most recent common ancestor (TMRCA) of all OP354-like P[8] genes was estimated at 1987. However, most OP354-like P[8] strains were found in three main clusters with TMRCAs estimated between 1996 and 2001. The VP7 gene segment of OP354-like P[8] strains showed evidence of frequent reassortment, even in localized epidemics, suggesting that OP354like P[8] genes behave in a similar manner on the evolutionary level as other P[8] subtypes. The results of this study suggest that OP354-like P[8] strains have been able to disperse globally in a relatively short time period. This, in combination with a relatively large genetic distance to other P[8] subtypes, might result in a lower vaccine effectiveness, underscoring the need for a continued surveillance of OP354-like P[8] strains, especially in countries where rotavirus vaccination programs are in place. | en_US |
dc.identifier.other | doi: 10.1093/molbev/msv088 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/24120 | |
dc.language.iso | en | en_US |
dc.publisher | Molecular Biology and Evolution | en_US |
dc.subject | OP354-like P[8] | en_US |
dc.subject | rotaviruses | en_US |
dc.subject | emerging viruses | en_US |
dc.subject | reassortment | en_US |
dc.title | Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents | en_US |
dc.type | Article | en_US |
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