Crystallization of linde type a nanomaterials at two temperatures exhibit differential inhibition of HeLa cervical cancer cells in vitro

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dc.contributor.authorTiburu, E.K.
dc.contributor.authorFleischer, H.N.A.
dc.contributor.authorAidoo, E.O.
dc.contributor.authorSalifu, A.A.
dc.contributor.authorAsimeng, B.O.
dc.contributor.authorZhou, H.
dc.date.accessioned2019-04-16T11:08:23Z
dc.date.available2019-04-16T11:08:23Z
dc.date.issued2016
dc.description.abstractThis work reports evidence of the synthesis of zeolite A at two different temperatures (60 °C and 105 °C) from kaolin. XRD spectral analysis revealed percent crystallinity of 74 ± 2 and 71 ± 3 in LTA60 and LTA105 respectively. The average crystallize size of LTA60 and LTA105 was also estimated using Scherrer's equation to be 57 nm. FTIR analysis showed signature peaks characteristics of zeolite A in the two materials, except the appearance of absorbance peak at 2380 cm-1 in the LTA60 spectrum which was not observed in LTA105. Nitrogen porosity measurements of LTA60 and LTA105 gave the following parameters: average pore width of 2.45 and 1.01 nm respectively for LTA60 and LTA105, surface areas of 19.18 and 8.00 m2/g and pore volume of 0.012 and 0.002 cm3/g in that order. The influence of the materials on HeLa cancer cell growth was also investigated and the results showed differential inhibitory effects with LTA60 revealing pronounced inhibitory effects compared to LTA105 after 72 hours of cell incubation. This studies highlighted the importance of crystallization conditions that could influence the physicochemical parameters including structure, porosity, size, and morphology of zeolite materials on cell activity. The work also provided unique opportunities for utilizing natural deposits of kaolin globally to fabricate biomimetic materials for various biological applications. © 2016 Trans Tech Publications, Switzerland.en_US
dc.identifier.citationE. K. Tiburu et al., "Crystallization of Linde Type A Nanomaterials at Two Temperatures Exhibit Differential Inhibition of HeLa Cervical Cancer Cells In Vitro", Journal of Biomimetics, Biomaterials and Biomedical Engineering, Vol. 28, pp. 66-77, 2016en_US
dc.identifier.issn22969837
dc.identifier.other10.4028/www.scientific.net/JBBBE.28.66
dc.identifier.othervol. 28, pp. 66-77, 2016
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/29300
dc.language.isoenen_US
dc.publisherTrans Tech Publications Ltden_US
dc.subjectAluminosilicateen_US
dc.subjectCanceren_US
dc.subjectCrystallizationen_US
dc.subjectNanomaterialsen_US
dc.subjectScanningen_US
dc.subjectZeoliteen_US
dc.titleCrystallization of linde type a nanomaterials at two temperatures exhibit differential inhibition of HeLa cervical cancer cells in vitroen_US
dc.typeArticleen_US

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