Progress toward elimination of perinatal HIV transmission in Kenya: Analysis of early infant diagnosis data

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dc.contributor.authorAchwoka, D.
dc.contributor.authorMandala, J.
dc.contributor.authorMuriithi, M.
dc.contributor.authorZeng, Y.
dc.contributor.authorChen, M.
dc.contributor.authorDirks, R.
dc.contributor.authorSirengo, M.
dc.contributor.authorWafula, R.
dc.contributor.authorTorpey, K.
dc.date.accessioned2019-07-05T09:45:38Z
dc.date.available2019-07-05T09:45:38Z
dc.date.issued2018-06
dc.description.abstractInterrupting vertical transmission of HIV from mothers to infants provides opportunity to transform the HIV/AIDS epidemic by eliminating new infections among children. We estimate mother-to-child transmission rates of infants born to known HIV-positive mothers offered prevention of mother-to-child transmission interventions and provide an indication of Kenya’s progress toward elimination of perinatal transmission. We obtained from the Kenya National Early Infant Diagnosis (EID) database, all 131,451 DNA polymerase chain reaction test results of HIV-exposed infants aged 0–18 months who had dried blood spot samples taken between January 2008 and October 2013. The majority of samples were from infants aged 0–6 months (81.0%). Infants aged 6–12 months comprised 15.5%, while those aged 12–18 months were 3.5%. Overall, 11,439 (8.7%) were HIV-positive. Positivity rates were higher among older age groups: 6.8, 14.6, and 27.5% in age groups 0–6 months, 6–12 months, and 12–18 months old, respectively. In Kenya, scale-up and decentralization to primary health centers of EID services has been remarkable. Both increasing HIV-positivity trends in age groups 12–18 months and differences between provinces require further interrogation. Although significant, declining HIV-positivity trends in age groups 0–6 months and 6–12 months old observed between 2008 and 2013 is insufficient to achieve the elimination agenda.en_US
dc.identifier.otherhttps://doi.org/10.1177/0956462417724015
dc.identifier.otherVolume: 29 issue: 7, page(s): 632-640
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/31269
dc.language.isoenen_US
dc.publisherInternational Journal of STD and AIDSen_US
dc.subjectEarly infant diagnosisen_US
dc.subjectPrevention of mother-to-child transmissionen_US
dc.subjectHIV transmissionen_US
dc.subjectKenyaen_US
dc.subjectSub-Saharan Africaen_US
dc.titleProgress toward elimination of perinatal HIV transmission in Kenya: Analysis of early infant diagnosis dataen_US
dc.typeArticleen_US

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