Effect of Enhanced Adherence Package on Early ART Uptake Among HIV-Positive Pregnant Women in Zambia: An Individual Randomized Controlled Trial

dc.contributor.authorMubiana-Mbewe, M.
dc.contributor.authorBosomprah, S.
dc.contributor.authorKadota, J.L.
dc.contributor.authoret.al
dc.date.accessioned2024-09-10T15:21:35Z
dc.date.available2024-09-10T15:21:35Z
dc.date.issued2021
dc.descriptionResearch Article
dc.description.abstractWe evaluated the effect of an option B-plus Enhanced Adherence Package (BEAP), on early ART uptake in a randomized controlled trial. HIV-positive, ART naïve pregnant women in Lusaka, Zambia was randomized to receive BEAP (phone calls/home visits, additional counseling, male partner engagement, and missed-visit follow-up) versus standard of care (SOC). The primary outcome was initiating and remaining on ART for 30 days. Analysis was by intention to treat (ITT) using logistic regression. An additional per-protocol analysis was done. We enrolled 454 women; 229 randomized to BEAP and 225 to SOC. Within 30 days of eligibility, 445 (98.2%) initiated ART. In ITT analysis, 82.5% BEAP versus 80.4% SOC participants reached the primary outcome (crude relative risk [RR] 1.03; 95% confidence interval [CI] 0.91–1.16; Wald test statistic = 0.44; p-value = 0.66). As per protocol analysis, (92 participants (40.2%) were excluded), 91.9% BEAP versus 80.4% SOC participants reached primary outcome (crude RR 1.14; 95% CI 1.02–1.29; Wald test statistic = 2.23; p-value = 0.03). Early ART initiation in pregnancy was nearly universal but there was an early drop out suggesting the need for additional adherence support.
dc.identifier.otherdoi:10.1007/s10461-020-03060-4
dc.identifier.urihttps://ugspace.ug.edu.gh/handle/123456789/42483
dc.language.isoen
dc.publisherAIDS and Behavior
dc.relation.ispartofseriesVol.; 25
dc.relation.ispartofseriesNo.; 3
dc.subjectHIV seropositivity
dc.subjectPregnant women
dc.subjectAntiretroviral therapy
dc.subjectOption B + uptake
dc.subjectEnhanced adherence
dc.titleEffect of Enhanced Adherence Package on Early ART Uptake Among HIV-Positive Pregnant Women in Zambia: An Individual Randomized Controlled Trial
dc.typeArticle

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