Efficacy of intravitreal ziv-aflibercept in patients with macular edema following retinal vein occlusion in Korle-Bu Teaching Hospital, Ghana: a retrospective case series
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Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
springer
Abstract
To evaluate the efficacy of ziv-aflibercept in
Ghanaian patients with macular edema (ME) secondary to retinal vein occlusion (RVO).
Methodology In this retrospective study, the medical
records of patients with ME secondary to RVO who
had been treated with intravitreal ziv-aflibercept (IVZ)
(1.25 mg/0.05 ml), as part of routine clinical practice,
on pro re nata basis with a minimum follow-up of
6 months were retrieved and analyzed. The main
outcome measures are mean change in best-corrected
visual acuity (BCVA) and central subfield foveal
thickness (CSFT) measured on optical coherence
tomography from baseline to 12 months post-IVZ,
and ocular and systemic safety. Results Forty-three eyes were included in this study.
Their mean age was 62.8 ± 11.9 years, 67.4% had at
least 12-month duration of follow-up, 50% had
primary open-angle glaucoma and 38 (88.4%) eyes
were treatment naive. There was significant improve ment in mean BCVA in LogMAR at 1 month post initiation of IVZ (0.8 ± 0.5 vs. 1.1 ± 0.6), and visual
improvement was maintained up to 12 months
(p\0.001). Eyes with ME following BRVO had
better mean BCVA at baseline and on subsequent
visits compared to eyes with CRVO/HRVO
(p = 0.01). There was significant reduction in mean
CSFT up to 12 months post-IVZ injection compared
to baseline (p\0.001). Ocular complications
observed were consistent with complications associ ated with RVO. We have observed significant improvement in functional and anatomic outcomes 12 months
post-initiation of IVZ. There is the need to confirm
long-term efficacy and safety of IVZ in a large
prospective study.
Description
Research Article
Keywords
Optical coherence tomography, Cystoid macular edema, Branch retinal vein occlusion, Central retinal vein occlusion, Hemi-retinal vein occlusion