High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana

dc.contributor.authorNichols, J.S.
dc.contributor.authorKyriakides, T.C.
dc.contributor.authorAntwi, S.
dc.contributor.authorRenner, L.
dc.contributor.authorLartey, M.
dc.contributor.authorSeaneke, O.A.
dc.contributor.authorObeng, R.
dc.contributor.authorCatlin, A.C.
dc.contributor.authorGan, G.
dc.contributor.authorReynolds, N.R.
dc.contributor.authorPaintsil, E.
dc.contributor.authorSankofa Study Team
dc.date.accessioned2019-06-06T09:22:51Z
dc.date.available2019-06-06T09:22:51Z
dc.date.issued2019-01
dc.description.abstractAdherence to antiretroviral therapy (ART) remains one of the greatest obstacles in pediatric HIV care. We sought to determine the prevalence of adherence to ART among undisclosed HIV-infected children and adolescents in Ghana. We analyzed baseline data from HIV-infected children and adolescents aged 7–18 years old enrolled in the SANKOFA Pediatric HIV disclosure intervention study in Ghana. Antiretroviral medication adherence was measured using caregiver 3-day recall; child 3-day recall; and pharmacy records for antiretroviral time-to-refill. Four hundred and twenty child-caregiver dyads were enrolled from January 2013 to June 2016. The median adherence (interquartile range), as measured by time-to-refill, was 93.2% (68.0%–100.0%). However, only 47.5% of children had ≥95% adherence (“good adherence”) using time-to-refill data. Children of caregivers who had received secondary or higher level of education versus no school (aOR, 2.90, 95% Confidence Interval, CI 1.29–6.56), p = 0.010) or elementary education only (aOR, 2.20, CI, 1.24–3.88, p = 0.007) were more likely to have “good adherence” (≥95%). In this cohort of children unaware of their HIV positive status, median ART adherence rate was sub-optimal (by World Health Organization definition) while 38% had poor adherence (<85%).en_US
dc.identifier.otherhttps://doi.org/10.1080/09540121.2018.1524113
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30515
dc.language.isoenen_US
dc.publisherAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIVen_US
dc.subjectAdherenceen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectPediatricsen_US
dc.titleHigh prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghanaen_US
dc.typeArticleen_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.6 KB
Format:
Item-specific license agreed upon to submission
Description: