High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana
dc.contributor.author | Nichols, J.S. | |
dc.contributor.author | Kyriakides, T.C. | |
dc.contributor.author | Antwi, S. | |
dc.contributor.author | Renner, L. | |
dc.contributor.author | Lartey, M. | |
dc.contributor.author | Seaneke, O.A. | |
dc.contributor.author | Obeng, R. | |
dc.contributor.author | Catlin, A.C. | |
dc.contributor.author | Gan, G. | |
dc.contributor.author | Reynolds, N.R. | |
dc.contributor.author | Paintsil, E. | |
dc.contributor.author | Sankofa Study Team | |
dc.date.accessioned | 2019-06-06T09:22:51Z | |
dc.date.available | 2019-06-06T09:22:51Z | |
dc.date.issued | 2019-01 | |
dc.description.abstract | Adherence to antiretroviral therapy (ART) remains one of the greatest obstacles in pediatric HIV care. We sought to determine the prevalence of adherence to ART among undisclosed HIV-infected children and adolescents in Ghana. We analyzed baseline data from HIV-infected children and adolescents aged 7–18 years old enrolled in the SANKOFA Pediatric HIV disclosure intervention study in Ghana. Antiretroviral medication adherence was measured using caregiver 3-day recall; child 3-day recall; and pharmacy records for antiretroviral time-to-refill. Four hundred and twenty child-caregiver dyads were enrolled from January 2013 to June 2016. The median adherence (interquartile range), as measured by time-to-refill, was 93.2% (68.0%–100.0%). However, only 47.5% of children had ≥95% adherence (“good adherence”) using time-to-refill data. Children of caregivers who had received secondary or higher level of education versus no school (aOR, 2.90, 95% Confidence Interval, CI 1.29–6.56), p = 0.010) or elementary education only (aOR, 2.20, CI, 1.24–3.88, p = 0.007) were more likely to have “good adherence” (≥95%). In this cohort of children unaware of their HIV positive status, median ART adherence rate was sub-optimal (by World Health Organization definition) while 38% had poor adherence (<85%). | en_US |
dc.identifier.other | https://doi.org/10.1080/09540121.2018.1524113 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/30515 | |
dc.language.iso | en | en_US |
dc.publisher | AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV | en_US |
dc.subject | Adherence | en_US |
dc.subject | Sub-Saharan Africa | en_US |
dc.subject | Antiretroviral therapy | en_US |
dc.subject | Pediatrics | en_US |
dc.title | High prevalence of non-adherence to antiretroviral therapy among undisclosed HIV-infected children in Ghana | en_US |
dc.type | Article | en_US |
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