In Vivo Assessment Of The Toxic Potential Of Dissotis Rotundifolia Whole Plant Extract In Sprague–Dawley Rats
Date
2016-06-03
Journal Title
Journal ISSN
Volume Title
Publisher
Asian Pacific Journal of Tropical Biomedicine
Abstract
Objective: To assess the toxic potential of Dissotis rotundifolia (D. rotundifolia) whole
plant extract in Spraque–Dawley rats within a 2-week period of administration.
Methods: Methanolic extract of D. rotundifolia was administered orally once daily at
dose levels of 0, 100, 300 and 1000 mg/kg body weight for 14 days. Toxicity was
assessed using mortality, clinical signs, body and organ weights, hematological indices,
serum chemistry parameters and histopathological analyses.
Results: There were no treatment-related mortalities or differences in clinical signs,
hematology and serum biochemistry. This was confirmed by micrographs obtained from
histopathological analysis.
Conclusions: The results obtained from the sub-acute toxicological assessment of
D. rotundifolia extract suggest that the extract is non-toxic at doses up to 1000 mg/kg/day
administered for a period of 14 days.
Description
Article
Keywords
Dissotis rotundifolia, Ghana, Melastomataceae, Toxic potential