Transient Impact of Dysglycemia on Sputum Conversion among Smear-Positive Tuberculosis Patients in a Tertiary Care Facility in Ghana
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
SAGE
Abstract
BACKGROUND: Apart from increasing the risk of tuberculosis (TB), diabetes may be associated with more severe disease and lower rates of
sputum conversion among TB patients.
METHODS: We conducted a baseline cross-sectional study with a longitudinal follow-up of newly diagnosed smear-positive TB patients for 6
months. Sputum conversion rates between those with dysglycemia and those without were compared at 2 months (end of the intensive
phase) and 6 months (end of the treatment). Descriptive statistics and logistic regression were computed to assess factors associated with dys glycemia as well as sputum conversion.
RESULTS: A significantly higher proportion of normoglycemic patients had negative sputum compared with those with dysglycemia (83% vs
67%, P-value < .05) at 2 months but not at 6 months (87% vs 77%, P-value > .05). After controlling for age group and adjusting for other covariates,
patients with dysglycemia were 66% less likely to convert sputum than those with normoglycemia. Females were at least 7 times more likely than
males and those with high waist-to-hip ratio (WHR) of 88% were less likely compared with those with low WHR for sputum conversion at 2 months,
respectively. At 6 months, females (compared with males) and those with high WHR (compared with those with normal WHR) were at over 9 times
increased odds and 89% less likely for sputum conversion, respectively.
CONCLUSION: A significantly lower proportion of smear-positive TB patients with dysglycemia converted to smear negative after 2 months of
treatment but not at the end of the treatment, thus suggesting a transient impact of dysglycemia on sputum conversion.
Description
Research Article
Keywords
Tuberculosis, smear Positive, dysglycemia, sputum Conversion, transient