Cost-effectiveness analysis of alcohol handrub for the prevention of neonatal bloodstream infections: Evidence from HAIGhana study

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dc.contributor.authorFenny, A.P.
dc.contributor.authorOtieku, E.
dc.contributor.authorLabi, K.A-K.
dc.contributor.authorAsante, F.A.
dc.contributor.authorEnemark, U.
dc.date.accessioned2022-04-26T09:56:51Z
dc.date.available2022-04-26T09:56:51Z
dc.date.issued2022
dc.descriptionResearch Articleen_US
dc.description.abstractPublished evidence of the cost-effectiveness of alcohol-based handrub (ABH) for the prevention of neonatal bloodstream infections (BSI) is limited in sub-Saharan Africa. Therefore, this study evaluates the cost-effectiveness of a multimodal hand hygiene involving alcoholbased hand rub (ABH) for the prevention of neonatal BSI in a neonatal intensive care unit (NICU) setting in Ghana using data from HAI-Ghana study. Design was a before and after intervention study using economic evaluation model to assess the cost-effectiveness of a multimodal hand hygiene strategy involving alcohol-based hand rub plus soap and water compared to existing practice of using only soap and water. We measured effect and cost by subtracting outcomes without the intervention from outcomes with the intervention. The primary outcome measure is the number of neonatal BSI episode averted with the intervention and the consequent cost savings from patient and provider perspectives. The before and after intervention studies lasted four months each, spanning October 2017 to January 2018 and December 2018 to March 2019, respectively. The analysis shows that the ABH program was effective in reducing patient cost of neonatal BSI by 41.7% and BSI-attributable hospital cost by 48.5%. Further, neonatal BSI-attributable deaths and extra length of hospital stay (LOS) decreased by 73% and 50% respectively. Also, the post-intervention assessment revealed the ABH program contributed to 16% decline in the incidence of neonatal BSI at the NICU. The intervention is a simple and adaptable strategy with cost-saving potential when carefully scaled up across the country. Though the cost of the intervention may be more relative to using just soap and water for hand hygiene, the outcome is a good reason for investment into the intervention to reduce the incidence of neonatal BSI and the associated costs from patient and providers’ perspectives.en_US
dc.identifier.otherhttps://doi.org/ 10.1371/journal.pone.0264905
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37943
dc.language.isoenen_US
dc.publisherPLOS ONEen_US
dc.subjectcost-effectivenessen_US
dc.subjectalcohol-based handrub (ABH)en_US
dc.subjectneonatal bloodstream infections (BSI)en_US
dc.subjectSub-Saharan Africaen_US
dc.subjectGhanaen_US
dc.titleCost-effectiveness analysis of alcohol handrub for the prevention of neonatal bloodstream infections: Evidence from HAIGhana studyen_US
dc.typeArticleen_US

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