Effect of Asymptomatic Plasmodium falciparum Parasitaemia on Platelets Thrombogenicity in Blood Donors

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dc.contributor.authorAninagyei, E.
dc.contributor.authorAdu, P.
dc.contributor.authorRufai, T.
dc.contributor.authorAmpomah, P.
dc.contributor.authorKwakye-Nuako, G.
dc.contributor.authorEgyir-Yawson, A.
dc.contributor.authorAcheampong, D.O.
dc.date.accessioned2021-11-08T13:10:01Z
dc.date.available2021-11-08T13:10:01Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractCurrently, blood donors in Ghana are not screened for malaria parasites. Therefore, this study assessed platelet thrombogenicity in blood donors infected asymptomatically with Plasmodium falciparum and the relationship between tumour necrosis factor alpha (TNFa), 8-iso-prostaglandin F2a oxidative stress biomarker (8- iso-PG2a), C-reactive protein (hs-CRP) and D-dimer, and platelet thrombogenes levels. Haematology analyser was used to enumerate platelet count and platelet indices in 80 P. falciparum infected blood donors and 160 matched noninfected controls. Replicate serum levels of von Willebrand Factor (vWF), platelet factor 4 (PF4), P-selectin thrombogenic factors as well as TNF-a and 8-iso-PG2a were determined using enzyme immuno-assay while high sensitive hs-CRP and D-dimer concentrations were determined by fluorescent immunoassay. The geometric mean of parasite density in malaria infected donors was 1784 parasites/ lL (505-2478 parasites/lL). This led to significant increase in the mean levels of 8-iso-PG2a, hs-CRP, TNF-a and D-dimer. However, PF4, P-selectin were significantly lower in infected donors while vWF levels did not differ significantly among the groups even though lower levels were observed in the infected donors. Significant direct relationship existed between both P-selectin and PF4 and platelet count, and plateletcrit and platelet large cell ratio whereas these thrombogenic factors varied inversely to 8-iso-PG2a, TNF-a and hs-CRP. Relative thrombocytopaenia was associated with significant reduction in P-selectin and platelet factor 4 levels together with increased 8-iso-PG2a, hs-CRP, TNF-a and D-dimer levels. Taken together, it is recommended that all P. falciparum infected blood donors should be deferred.en_US
dc.identifier.otherhttps://doi.org/10.1007/s12288-020-01390-w
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37025
dc.language.isoenen_US
dc.publisherIndian Journal of Hematology and Blood Transfusionen_US
dc.subjectPlatelet thrombogenicityen_US
dc.subjectPlatelet factor 4en_US
dc.subjectP-selectinen_US
dc.subject8-iso-prostaglandin F2aen_US
dc.subjectThrombocytopaeniaen_US
dc.subjectBlood donorsen_US
dc.titleEffect of Asymptomatic Plasmodium falciparum Parasitaemia on Platelets Thrombogenicity in Blood Donorsen_US
dc.typeArticleen_US

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