Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications
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Hindawi
Abstract
pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of
analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their
pharmacological relevance in diabetes mellitus. Aim of the Study. 'e present review was to compile results from in vitro and in
vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic
online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have
collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin
in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting
diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes
mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and
application research.
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Research Article
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https://doi.org/10.1155/2021/6641128