Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

dc.contributor.authorLarsen, M.D.
dc.contributor.authorLopez-Perez, M.
dc.contributor.authorDickson, E.K.
dc.contributor.authorAmpomah, P.
dc.contributor.authorEderveen, H.
dc.contributor.authorKoeleman, C.A.M.
dc.contributor.authorNouta, J.
dc.contributor.authorNdam, T.
dc.contributor.authorMordmüller, B.
dc.contributor.authorSalanti, A.
dc.contributor.authorNielsen, M.A.
dc.contributor.authorMassougbodji, A.
dc.contributor.authorSchoot, C.E.
dc.contributor.authorOfori, M.F.
dc.contributor.authorWuhrer, M.
dc.contributor.authorHviid, L.
dc.contributor.authorVidarsson, G.
dc.date.accessioned2021-11-17T10:33:16Z
dc.date.available2021-11-17T10:33:16Z
dc.date.issued2021
dc.descriptionResearch Articleen_US
dc.description.abstractPlasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate receptor- and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody responses are a central component of naturally acquired malaria immunity. PfEMP1-specific IgG likely protects by inhibiting IE sequestration and through IgG-Fc Receptor (FcγR) mediated phagocytosis and killing of antibody-opsonized IEs. The affinity of afucosylated IgG to FcγRIIIa is up to 40-fold higher than fucosylated IgG, resulting in enhanced antibodydependent cellular cytotoxicity. Most IgG in plasma is fully fucosylated, but afucosylated IgG is elicited in response to enveloped viruses and to paternal alloantigens during pregnancy. Here we show that naturally acquired PfEMP1-specific IgG is strongly afucosylated in a stable and exposure-dependent manner, and efficiently induces FcγRIIIa-dependent natural killer (NK) cell degranulation. In contrast, immunization with a subunit PfEMP1 (VAR2CSA) vaccine results in fully fucosylated specific IgG. These results have implications for understanding protective natural- and vaccine-induced immunity to malaria.en_US
dc.identifier.otherhttps://doi.org/10.1038/s41467-021-26118-w
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/37142
dc.language.isoenen_US
dc.publisherNATURE COMMUNICATIONSen_US
dc.subjectimmunityen_US
dc.subjectPlasmodiumen_US
dc.subjectAfucosylateden_US
dc.subjectvaccinationen_US
dc.subjectplasmaen_US
dc.subjectMalariaen_US
dc.titleAfucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccinationen_US
dc.typeArticleen_US

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