Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi experimental study

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dc.contributor.authorOtieku, E.
dc.contributor.authorFenny, A.P.
dc.contributor.authorLabi, A-K.
dc.contributor.authorOwusu-Ofori, A.K.
dc.contributor.authorKurtzhals, J.
dc.contributor.authorEnemark, U.
dc.date.accessioned2023-04-21T17:43:23Z
dc.date.available2023-04-21T17:43:23Z
dc.date.issued2023
dc.descriptionResearch Articleen_US
dc.description.abstractObjective To evaluate knowledge of antimicrobial resistance (AMR), to study how the judgement of health value (HVJ) and economic value (EVJ) affects antibiotic use, and to understand if access to information on AMR implications may influence perceived AMR mitigation strategies. Design A quasi-experimental study with interviews performed before and after an intervention where hospital staff collected data and provided one group of participants with information about the health and economic implications of antibiotic use and resistance compared with a control group not receiving the intervention. Setting Korle-Bu and Komfo Anokye Teaching Hospitals, Ghana. Participants Adult patients aged 18 years and older seeking outpatient care. Main outcome measures We measured three outcomes: (1) level of knowledge of the health and economic implications of AMR; (2) HVJ and EVJ behaviours influencing antibiotic use and (3) differences in perceived AMR mitigation strategy between participants exposed and not exposed to the intervention. Results Most participants had a general knowledge of the health and economic implications of antibiotic use and AMR. Nonetheless, a sizeable proportion disagreed or disagreed to some extent that AMR may lead to reduced productivity/indirect costs (71% (95% CI 66% to 76%)), increased provider costs (87% (95% CI 84% to 91%)) and costs for carers of AMR patients/societal costs (59% (95% CI 53% to 64%)). Both HVJ-driven and EVJ-driven behaviours influenced antibiotic use, but the latter was a better predictor (reliability coefficient >0.87). Compared with the unexposed group, participants exposed to the intervention were more likely to recommend restrictive access to antibiotics (p<0.01) and pay slightly more for a health treatment strategy to reduce their risk of AMR (p<0.01). Conclusion There is a knowledge gap about antibiotic use and the implications of AMR. Access to AMR information at the point of care could be a successful way to mitigate the prevalence and implications of AMR.en_US
dc.identifier.citationTo cite: Otieku E, Fenny AP, Labi A-K, et al. Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi experimental study. BMJ Open 2023;13:e065233. doi:10.1136/ bmjopen-2022-065233en_US
dc.identifier.otherdoi:10.1136/ bmjopen-2022-065233
dc.identifier.urihttp://ugspace.ug.edu.gh:8080/handle/123456789/38920
dc.language.isoenen_US
dc.publisherBMJ Openen_US
dc.subjectKnowledgeen_US
dc.subjectattitudesen_US
dc.subjectpracticesen_US
dc.subjectantimicrobial useen_US
dc.subjectGhanaen_US
dc.titleKnowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi experimental studyen_US
dc.typeArticleen_US

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