Minimal variation in a vaccine candidate from the sexual stage of plasmodium falciparum.
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Molecular and Biochemical Parasitology
Abstract
L'antigène de surface de 25 KDa (Pfs25) des zygotes et askinetes est un premier candidat pour un vaccin bloquant la transmission. On a récemment isolé le gène codant Pfs25. L'explication la plus probable du manque de variation de l'antigène est que Pfs25 n'est exprimé que lorsque le parasite est chez le moustique
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Keywords
EMTREE drug terms: membrane antigen, EMTREE medical terms: animal cell; antigenic variation; dna sequence; nonhuman; ookinete; plasmodium falciparum; preliminary communication; protozoon; zygote, MeSH: Amino Acid Sequence; Animal; Antigenic Variation; Antigens, Protozoan; Antigens, Surface; Base Sequence; DNA Mutational Analysis; Exons; Molecular Sequence Data; Nucleic Acid Amplification Techniques; Plasmodium falciparum; Support, Non-U.S. Gov't; Vaccines
Citation
Kaslow, D. C., Quakyi, I. A., &Keister, D. B. (1989). Minimal variation in a vaccine candidate from the sexual stage of plasmodium falciparum. Molecular and Biochemical Parasitology, 32(1), 101-103.