Reduction in the urinary aflatoxin M1 biomarker as an early indicator of the efficacy of dietary interventions to reduce exposure to aflatoxins

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dc.contributor.authorMitchell, N.J.
dc.contributor.authorKumi, J.
dc.contributor.authorJohnson, N.M.
dc.contributor.authorDotse, E.
dc.contributor.authorMarroquin-Cardona, A.
dc.contributor.authorWang, J.S.
dc.contributor.authorJolly, P.E.
dc.contributor.authorAnkrah, N.-A.
dc.contributor.authorPhillips, T.D.
dc.date.accessioned2018-12-11T15:08:59Z
dc.date.available2018-12-11T15:08:59Z
dc.date.issued2013-05
dc.description.abstractAflatoxin B1 is a persistent public health issue in Ghana. Assessment of AFB1 intervention efficacy is currently dependent on long-term biomarkers. This study was designed to determine whether daily AFM1 biomarker levels could be utilized as an early detection method for intervention efficacy. Participants were treated with a refined calcium montmorillonite clay (UPSN) or a placebo (calcium carbonate) in a crossover study. Urine samples were assessed for AFM1 levels daily. UPSN treatment reduced AFM1 biomarkers by 55% compared to the placebo. This is the first study to show that daily urinary AFM1 levels can be used as a biomarker of internal aflatoxin B1 exposure in short-term intervention trials to determine efficacy. © 2013 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.en_US
dc.identifier.otherhttps://doi.org/10.3109/1354750X.2013.798031
dc.identifier.otherVolume 18, Issue 5, Pages 391-398
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/26332
dc.language.isoenen_US
dc.publisherBiomarkersen_US
dc.subjectAflatoxinen_US
dc.subjectEnterosorption therapyen_US
dc.subjectGhanaen_US
dc.subjectLiver canceren_US
dc.titleReduction in the urinary aflatoxin M1 biomarker as an early indicator of the efficacy of dietary interventions to reduce exposure to aflatoxinsen_US
dc.typeArticleen_US

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