Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa
dc.contributor.author | Asare, P. | |
dc.contributor.author | Asante-Poku, A. | |
dc.contributor.author | Prah, D.A. | |
dc.contributor.author | Borrell, S. | |
dc.contributor.author | Osei-Wusu, S. | |
dc.contributor.author | Otchere, I.D. | |
dc.contributor.author | Forson, A. | |
dc.contributor.author | Adjapong, G. | |
dc.contributor.author | Koram, K.A. | |
dc.contributor.author | Gagneux, S. | |
dc.contributor.author | Yeboah-Manu, D. | |
dc.date.accessioned | 2019-02-04T12:23:42Z | |
dc.date.available | 2019-02-04T12:23:42Z | |
dc.date.issued | 2018-08 | |
dc.description.abstract | Objective: Understanding transmission dynamics is useful for tuberculosis (TB) control. A population-based molecular epidemiological study was conducted to determine TB transmission in Ghana. Methods: Mycobacterium tuberculosis complex (MTBC) isolates obtained from prospectively sampled pulmonary TB patients between July 2012 and December 2015 were characterized using spoligotyping and standard 15-locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) typing for transmission studies. Results: Out of 2309 MTBC isolates, 1082 (46.9%) unique cases were identified, with 1227 (53.1%) isolates belonging to one of 276 clusters. The recent TB transmission rate was estimated to be 41.2%. Whereas TB strains of lineage 4 belonging to M. tuberculosis showed a high recent transmission rate (44.9%), reduced recent transmission rates were found for lineages of Mycobacterium africanum (lineage 5, 31.8%; lineage 6, 24.7%). Conclusions: The study findings indicate high recent TB transmission, suggesting the occurrence of unsuspected outbreaks in Ghana. The observed reduced transmission rate of M. africanum suggests other factor(s) (host/environmental) may be responsible for its continuous presence in West Africa. © 2018 The Author(s) | en_US |
dc.identifier.other | DOI: 10.1016/j.ijid.2018.05.014 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/27206 | |
dc.language.iso | en | en_US |
dc.publisher | International Journal of Infectious Diseases | en_US |
dc.subject | MIRU-VNTR | en_US |
dc.subject | Molecular epidemiology | en_US |
dc.subject | Mycobacterium africanum | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | Spoligotyping | en_US |
dc.subject | Transmission | en_US |
dc.title | Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa | en_US |
dc.type | Article | en_US |
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