Reduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africa

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dc.contributor.authorAsare, P.
dc.contributor.authorAsante-Poku, A.
dc.contributor.authorPrah, D.A.
dc.contributor.authorBorrell, S.
dc.contributor.authorOsei-Wusu, S.
dc.contributor.authorOtchere, I.D.
dc.contributor.authorForson, A.
dc.contributor.authorAdjapong, G.
dc.contributor.authorKoram, K.A.
dc.contributor.authorGagneux, S.
dc.contributor.authorYeboah-Manu, D.
dc.date.accessioned2019-02-04T12:23:42Z
dc.date.available2019-02-04T12:23:42Z
dc.date.issued2018-08
dc.description.abstractObjective: Understanding transmission dynamics is useful for tuberculosis (TB) control. A population-based molecular epidemiological study was conducted to determine TB transmission in Ghana. Methods: Mycobacterium tuberculosis complex (MTBC) isolates obtained from prospectively sampled pulmonary TB patients between July 2012 and December 2015 were characterized using spoligotyping and standard 15-locus mycobacterial interspersed repetitive unit variable number tandem repeat (MIRU-VNTR) typing for transmission studies. Results: Out of 2309 MTBC isolates, 1082 (46.9%) unique cases were identified, with 1227 (53.1%) isolates belonging to one of 276 clusters. The recent TB transmission rate was estimated to be 41.2%. Whereas TB strains of lineage 4 belonging to M. tuberculosis showed a high recent transmission rate (44.9%), reduced recent transmission rates were found for lineages of Mycobacterium africanum (lineage 5, 31.8%; lineage 6, 24.7%). Conclusions: The study findings indicate high recent TB transmission, suggesting the occurrence of unsuspected outbreaks in Ghana. The observed reduced transmission rate of M. africanum suggests other factor(s) (host/environmental) may be responsible for its continuous presence in West Africa. © 2018 The Author(s)en_US
dc.identifier.otherDOI: 10.1016/j.ijid.2018.05.014
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/27206
dc.language.isoenen_US
dc.publisherInternational Journal of Infectious Diseasesen_US
dc.subjectMIRU-VNTRen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectMycobacterium africanumen_US
dc.subjectMycobacterium tuberculosisen_US
dc.subjectSpoligotypingen_US
dc.subjectTransmissionen_US
dc.titleReduced transmission of Mycobacterium africanum compared to Mycobacterium tuberculosis in urban West Africaen_US
dc.typeArticleen_US

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