Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy

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dc.contributor.authorDobaño, C.
dc.contributor.authorSanz, H.
dc.contributor.authorSorgho, H.
dc.contributor.authorDosoo, D.
dc.contributor.authorMpina, M.
dc.contributor.authorUbillos, I.
dc.contributor.authorAguilar, R.
dc.contributor.authorFord, T.
dc.contributor.authorDíez-Padrisa, N.
dc.contributor.authorWilliams, N.A.
dc.contributor.authorAyestaran, A.et.al.
dc.date.accessioned2019-05-27T10:12:51Z
dc.date.available2019-05-27T10:12:51Z
dc.date.issued2019-05
dc.description.abstractRTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p < 0.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between means), and higher concentrations and avidities in children than infants (p < 0.001). Baseline CSP IgG levels are elevated in malaria cases than controls (p < 0.001). Both, IgG magnitude to NANP (hazard ratio [95% confidence interval] 0.61 [0.48–0.76]) and avidity to C-terminus (0.07 [0.05–0.90]) post-vaccination are significantly associated with vaccine efficacy. IgG avidity to the C-terminus emerges as a significant contributor to RTS,S/AS01E-mediated protection.en_US
dc.identifier.otherdoi: 10.1038/s41467-019-10195-z
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/30285
dc.language.isoenen_US
dc.publisherNature Communicationsen_US
dc.subjectImmunologyen_US
dc.subjectInfectious diseasesen_US
dc.subjectVaccinesen_US
dc.subjectMicrobiologyen_US
dc.titleConcentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacyen_US
dc.typeArticleen_US

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