Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy
dc.contributor.author | Dobaño, C. | |
dc.contributor.author | Sanz, H. | |
dc.contributor.author | Sorgho, H. | |
dc.contributor.author | Dosoo, D. | |
dc.contributor.author | Mpina, M. | |
dc.contributor.author | Ubillos, I. | |
dc.contributor.author | Aguilar, R. | |
dc.contributor.author | Ford, T. | |
dc.contributor.author | Díez-Padrisa, N. | |
dc.contributor.author | Williams, N.A. | |
dc.contributor.author | Ayestaran, A.et.al. | |
dc.date.accessioned | 2019-05-27T10:12:51Z | |
dc.date.available | 2019-05-27T10:12:51Z | |
dc.date.issued | 2019-05 | |
dc.description.abstract | RTS,S/AS01E has been tested in a phase 3 malaria vaccine study with partial efficacy in African children and infants. In a cohort of 1028 subjects from one low (Bagomoyo) and two high (Nanoro, Kintampo) malaria transmission sites, we analysed IgG plasma/serum concentration and avidity to CSP (NANP-repeat and C-terminal domains) after a 3-dose vaccination against time to clinical malaria events during 12-months. Here we report that RTS,S/AS01E induces substantial increases in IgG levels from pre- to post-vaccination (p < 0.001), higher in NANP than C-terminus (2855 vs 1297 proportional change between means), and higher concentrations and avidities in children than infants (p < 0.001). Baseline CSP IgG levels are elevated in malaria cases than controls (p < 0.001). Both, IgG magnitude to NANP (hazard ratio [95% confidence interval] 0.61 [0.48–0.76]) and avidity to C-terminus (0.07 [0.05–0.90]) post-vaccination are significantly associated with vaccine efficacy. IgG avidity to the C-terminus emerges as a significant contributor to RTS,S/AS01E-mediated protection. | en_US |
dc.identifier.other | doi: 10.1038/s41467-019-10195-z | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/30285 | |
dc.language.iso | en | en_US |
dc.publisher | Nature Communications | en_US |
dc.subject | Immunology | en_US |
dc.subject | Infectious diseases | en_US |
dc.subject | Vaccines | en_US |
dc.subject | Microbiology | en_US |
dc.title | Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy | en_US |
dc.type | Article | en_US |
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