Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes
dc.contributor.author | Usui, M. | |
dc.contributor.author | Prajapati, S.K. | |
dc.contributor.author | Ayanful-Torgby, R. | |
dc.contributor.author | Acquah, F.K. | |
dc.contributor.author | Cudjoe, E. | |
dc.contributor.author | Kakaney, C. | |
dc.contributor.author | Amponsah, J.A. | |
dc.contributor.author | Obboh, E.K. | |
dc.contributor.author | Reddy, D.K. | |
dc.contributor.author | Barbeau, M.C.et.al. | |
dc.date.accessioned | 2019-05-27T10:05:54Z | |
dc.date.available | 2019-05-27T10:05:54Z | |
dc.date.issued | 2019-05 | |
dc.description.abstract | Plasmodium sexual differentiation is required for malaria transmission, yet much remains unknown about its regulation. Here, we quantify early gametocyte-committed ring (gc-ring) stage, P. falciparum parasites in 260 uncomplicated malaria patient blood samples 10 days before maturation to transmissible stage V gametocytes using a gametocyte conversion assay (GCA). Seventy six percent of the samples have gc-rings, but the ratio of gametocyte to asexual-committed rings (GCR) varies widely (0–78%). GCR correlates positively with parasitemia and is negatively influenced by fever, not hematocrit, age or leukocyte counts. Higher expression levels of GDV1-dependent genes, ap2-g, msrp1 and gexp5, as well as a gdv1 allele encoding H217 are associated with high GCR, while high plasma lysophosphatidylcholine levels are associated with low GCR in the second study year. The results provide a view of sexual differentiation in the field and suggest key regulatory roles for clinical factors and gdv1 in gametocytogenesis in vivo. | en_US |
dc.identifier.other | DOI: 10.1038/s41467-019-10172-6 | |
dc.identifier.uri | http://ugspace.ug.edu.gh/handle/123456789/30284 | |
dc.language.iso | en | en_US |
dc.publisher | Nature Communications | en_US |
dc.title | Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes | en_US |
dc.type | Article | en_US |
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