In Vitro Antimicrobial Effect of Encapsulated Vancomycin on Internalized Staphylococcus aureus Within Endothelial Cells Read More: http://informahealthcare.com/doi/abs/10.1080/03639040600867989
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Date
2007
Journal Title
Journal ISSN
Volume Title
Publisher
Drug Development and Industrial Pharmacy
Abstract
Vancomycin (VCN) is a glycopeptide antibiotic that is effective in the treatment of gram-positive bacterial infections, but mainly reserved for methicilin resistant Staphylococcus aureus. It is, however, ineffective against intracellular bacteria and hence a particulate form of VCN would be required. Bovine serum albumin (BSA) microspheres of VCN with a mean particle size of 5 ± 1.6 μm were used. Human microvascular endothelial cells internalized both S. aureus and VCN microspheres in a time and concentration-dependent manner, however, the uptake was inhibited by cytochalasin D. Action of VCN on S. aureus in the intracellular microenvironment decreased the bacterial load considerably.
Read More: http://informahealthcare.com/doi/abs/10.1080/03639040600867989
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Keywords
Endothelial cells, Cytochalasin D, Vancomycin, Microspheres, Bovine serum albumin Read More: http://informahealthcare.com/doi/abs/10.1080/03639040600867989
Citation
Nettey, H., Haswani, D., D'Souza, M., & Oettinger, C. (2007). In vitro antimicrobial effect of encapsulated vancomycin on internalized staphylococcus aureus within endothelial cells. Drug Development and Industrial Pharmacy, 33(2), 133-139.