Anticonvulsant and related neuropharmacological effects of the whole plant extract of synedrella nodiflora (L.) gaertn (asteraceae)

dc.contributor.authorAmoateng, P.
dc.contributor.authorWoode, E.
dc.contributor.authorKombian, S.B.
dc.date.accessioned2013-04-29T13:36:29Z
dc.date.accessioned2017-10-16T11:44:14Z
dc.date.available2013-04-29T13:36:29Z
dc.date.available2017-10-16T11:44:14Z
dc.date.issued2012
dc.description.abstractPURPOSE:The plant Synedrella nodiflora (L) Gaertn is traditionally used by some Ghanaian communities to treat epilepsy. To determine if this use has merit, we studied the anticonvulsant and other neuropharmacological effects of a hydro-ethanolic extract of the whole plant using murine models. MATERIALS AND METHODS: The anticonvulsant effect of the extract (10-1000 mg/kg) was tested on the pentylenetetrazole-, picrotoxin-, and pilocarpine-induced seizure models and PTZ-kindling in mice/rats. The effect of the extract was also tested on motor coordination using the rota-rod. RESULTS: The results obtained revealed that the extract possesses anticonvulsant effects in all the experimental models of seizures tested as it significantly reduced the latencies to myoclonic jerks and seizures as well as seizure duration and the percentage severity. The extract was also found to cause motor incoordination at the higher dose of 1000 mg/kg. CONCLUSIONS: In summary, the hydro-ethanolic extract of the whole plant of S. nodiflora possesses anticonvulsant effects, possibly through an interaction with GABAergic transmission and antioxidant mechanisms and muscle relaxant effects. These findings thus provide scientific evidence in support of the traditional use of the plant in the management of epilepsy.en_US
dc.identifier.citationAmoateng, P., Woode, E., & Kombian, S. B. (2012). Anticonvulsant and related neuropharmacological effects of the whole plant extract of synedrella nodiflora (L.) gaertn (asteraceae). Journal of Pharmacy and Bioallied Sciences, 4(2), 140-148.en_US
dc.identifier.urihttp://197.255.68.203/handle/123456789/2742
dc.language.isoenen_US
dc.subjectKindlingen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectPicrotoxinen_US
dc.subjectPilocarpineen_US
dc.subjectSynedrella nodifloraen_US
dc.titleAnticonvulsant and related neuropharmacological effects of the whole plant extract of synedrella nodiflora (L.) gaertn (asteraceae)en_US
dc.typeArticleen_US

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