Analgesic activity and safety assessment of heliotropium indicum linn. (boraginaceae) in rodents

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dc.contributor.authorBoye, A.
dc.contributor.authorKoffuor, G.A.
dc.contributor.authorAmoateng, P.
dc.contributor.authorAmeyaw, E. O.
dc.contributor.authorAbaitey, A.K.
dc.date.accessioned2013-05-22T09:17:01Z
dc.date.accessioned2017-10-16T12:35:18Z
dc.date.available2013-05-22T09:17:01Z
dc.date.available2017-10-16T12:35:18Z
dc.date.issued2012
dc.description.abstractThis study presented the analgesic and safety assessment of Heliotropium indicum, a plant traditionally used for the management of abdominal pains, dysmenorrhoea and post-labour inflammatory conditions in Ghana using formalin-induced pain model in mice. For comparison of analgesic effect, morphine (1-10 mg kg-1) and diclofenac sodium (1-10 mg kg-1) were used as a reference opioid and NSAID, respectively. The aqueous and ethanolic extracts (30-300 mg kg-1) dose-dependently inhibited both the first and second phases of the formalin-induced nociception. Oral doses of the aqueous extract (1-5 g kg-1) in imprint control region mice were well tolerated in acute toxicity studies; however a 14-day oral administration of 1-2 g kg-1 of the extracts in sprague-Dawley rats produced pathologic effects on the heart, kidney, liver and lungs. Therefore, although the aqueous and ethanolic extracts of H. indicum have analgesic activity, it could have a cumulative toxic effects hence prolonged and continuous use is not advised.en_US
dc.identifier.citationBoye, A., Koffuor, G. A., Amoateng, P., Ameyaw, E. O., & Abaitey, A. K. (2012). Analgesic activity and safety assessment of heliotropium indicum linn. (boraginaceae) in rodents.en_US
dc.identifier.urihttp://scialert.net/abstract/?doi=ijp.2012.91.100
dc.identifier.urihttp://197.255.68.203/handle/123456789/2789
dc.language.isoenen_US
dc.subjectANALGESICS; HELIOTROPIUM; RODENTS as laboratory animals; HERBS -- Therapeutic use; ABDOMINAL pain -- Treatment; PHARMACOLOGYen_US
dc.titleAnalgesic activity and safety assessment of heliotropium indicum linn. (boraginaceae) in rodentsen_US
dc.typeArticleen_US

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