Hypoglycaemic activity of tragia tennifolia (euphorbiaceae) extract in rats
dc.contributor.author | Koffuor, GA | |
dc.contributor.author | Woode, E | |
dc.contributor.author | Amoateng, P | |
dc.date.accessioned | 2013-06-17T15:57:14Z | |
dc.date.accessioned | 2017-10-16T11:44:08Z | |
dc.date.available | 2013-06-17T15:57:14Z | |
dc.date.available | 2017-10-16T11:44:08Z | |
dc.date.issued | 2011 | |
dc.description.abstract | The hypoglycaemic effect of the ethanolic Tragia tennifolia Extract (TTE) was studied in Sprague-Dawley rats subjected to Oral Glucose Tolerance Test (OGTT), Fasting Plasma Glucose Test (FPGT) and alloxan-induced diabetes mellitus. Acute toxicity studies were also conducted on Sprague-Dawley rats. TTE (53 mg kg-1, p.o.) significantly (p≤0.01) reduced the peak plasma glucose concentration and the AUC of the OGTT curve, by 47.0 and 44.9%, respectively 1 h after its administration and this was comparable to that produced by glibenclamide (0.14 mg kg-1) and metformin (12.14 mg kg-1). TTE like glibenclamide, significantly (p≤0.01) reduced the fasting plasma glucose by 29.1% after 5 h compared to control groups. The AUC for TTE-treated rats was reduced by 14.8%. In alloxan-induced DM rats, insulin (8.5 unit/kg/day) significantly (p≤0.01) reduced hyperglycaemia by 68.6% whereas TTE, glibenclamide and metformin had no significant effects. Acute toxicity studies showed no evidence of toxicity after an oral administration of TTE (0.1-0.5 g kg-1). These results indicate that TTE may be potentially useful in Non-insulin Dependent Diabetes Mellitus (NIDDM) but not for Insulin Dependent Diabetes Mellitus (IDDM). | en_US |
dc.identifier.citation | Koffuor, G. A., Woode, E., & Amoateng, P. (2011). Hypoglycaemic activity of tragia tennifolia (euphorbiaceae) extract in rats. International Journal of Pharmacology, 7(6), 704-709. | en_US |
dc.identifier.uri | http://197.255.68.203/handle/123456789/3331 | |
dc.language.iso | en | en_US |
dc.publisher | International Journal of Pharmacology | en_US |
dc.subject | Tragia tennifolia | en_US |
dc.subject | Hyperglycaemia | en_US |
dc.subject | Oral Glucose Tolerance Test (OGTT) | en_US |
dc.subject | Non-insulin dependent diabetes mellitus | en_US |
dc.subject | Alloxan-induced diabetis mellitus | en_US |
dc.title | Hypoglycaemic activity of tragia tennifolia (euphorbiaceae) extract in rats | en_US |
dc.type | Article | en_US |