Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats

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dc.contributor.authorAmoateng, P.
dc.contributor.authorAdjei, S.
dc.contributor.authorOsei-Safo, D.
dc.contributor.authorKukuia, K.K.E.
dc.contributor.authorKretchy, I.A.
dc.contributor.authorSarkodie, J.A.
dc.contributor.authorN'Guessan, B.B.
dc.date.accessioned2017-10-31T10:48:36Z
dc.date.available2017-10-31T10:48:36Z
dc.date.issued2017
dc.description.abstractBackground: Synedrella nodiflora is used by traditional healers in Ghana for the management of epilepsy and pain. The hydro-ethanolic extract of the whole plant has demonstrated antinociceptive effect in various animal models of pain. This study investigated the potential benefit of the hydro-ethanolic extract in a rat model of paclitaxel-induced neuropathic pain. Methods: Neuropathy was induced in rats by a continuous intraperitoneal administration of paclitaxel (2 mg/kg) for 5 days. Baseline latencies to thermal pain were recorded before the first injection of paclitaxel and during the 5 day induction period. Following the induction, the rats in designated treatment group were treated with the hydro-ethanolic extract (100, 300 and 1000 mg/kg, p.o) or pregabalin (10, 30 and 100 mg/kg) or vehicle (distilled water) and their responses to thermal hyperalgesia measured every 30 for a total period of 3 h. Results: There was a significant difference between the baseline reaction latency and what was observed on the 5th day of the induction of neuropathy. Two days after the induction of neuropathy, the extract and pregabalin significantly and dose-dependently produced antinociceptive effect during the 3-h test period. Conclusion: The hydro-ethanolic extract of the whole plant of Synedrella nodiflora possess analgesic effect in paclitaxel-induced neuropathy in rats.en_US
dc.identifier.issn17560500
dc.identifier.other10.1186/s13104-017-2551-7
dc.identifier.urihttp://ugspace.ug.edu.gh/handle/123456789/22363
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.subjectNeuropathicen_US
dc.subjectPaclitaxelen_US
dc.subjectPainen_US
dc.subjectPregabalinen_US
dc.subjectSynedrellaen_US
dc.titleAnalgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in ratsen_US
dc.typeArticleen_US

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