dc.contributor.author |
Kyeremeh, K. |
|
dc.contributor.author |
Kwain, S. |
|
dc.contributor.author |
Tetevi, G.M. |
|
dc.contributor.author |
Camas, A.S. |
|
dc.contributor.author |
Camas, M. |
|
dc.contributor.author |
Dofuor, A.K. |
|
dc.contributor.author |
Deng, H. |
|
dc.contributor.author |
Jaspars, M. |
|
dc.date.accessioned |
2019-10-01T11:25:03Z |
|
dc.date.available |
2019-10-01T11:25:03Z |
|
dc.date.issued |
2019-06-14 |
|
dc.identifier.other |
doi:10.3390/M1066 |
|
dc.identifier.uri |
http://ugspace.ug.edu.gh/handle/123456789/32372 |
|
dc.description |
Research Article |
en_US |
dc.description.abstract |
The Mycobacterium sp. BRS2A-AR2 is an endophyte of the mangrove plant Rhizophora racemosa G. Mey., which grows along the banks of the River Butre, in the Western Region of Ghana. Chemical profiling using 1H-NMR and HRESI-LC-MS of fermentation extracts produced by the strain led to the isolation of the new compound, α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d–fructofuranoside] or simply tortomycoglycoside (1). Compound 1 is an aminoglycoside consisting of a tryptophan moiety esterified to a disaccharide made up of β-d-fructofuranose and α-d-glucopyranose sugars. The full structure of 1 was determined using UV, IR, 1D, 2D-NMR and HRESI-LC-MS data. When tested against Trypanosoma brucei subsp. brucei, the parasite responsible for Human African Trypanosomiasis in sub-Saharan Africa, 1 (IC50 11.25 µM) was just as effective as Coptis japonica (Thunb.) Makino. (IC50 8.20 µM). The extract of Coptis japonica (Thunb.) Makino. is routinely used as laboratory standard due to its powerful antitrypanosomal activity. It is possible that, compound 1 interferes with the normal uptake and metabolism of tryptophan in the T. brucei subsp. brucei parasite. |
en_US |
dc.description.sponsorship |
Centre for AfricanWetlands (CAW), University of Ghana.TWAS Research Grant Award, Cambridge-Africa Partnership for Research Excellence (CAPREx), which is funded by the Carnegie Corporation of New York, for a Postdoctoral Fellowship.Cambridge-Africa ALBORADA Research Fund for support and MRC African Research Leaders
MR/S00520X/1 Award.Carnegie BANGA-Africa Project Award |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Molbank |
en_US |
dc.relation.ispartofseries |
2019;2 |
|
dc.subject |
Endophytes |
en_US |
dc.subject |
Mangroves |
en_US |
dc.subject |
Glycosides |
en_US |
dc.subject |
Trypanosomes |
en_US |
dc.subject |
Antiparasitics |
en_US |
dc.title |
α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside] |
en_US |
dc.type |
Article |
en_US |