Research Articles
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A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community
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Item Endemic goitre and urinary iodine levels in rural communities in the Bolgatanga and Builsa districts of the upper east region of Ghana(East African Journal of Medicine, 1998-09) Asibey-Berko, E.; Amoah, A.G.; Addo, F.; Agyepong, E.Objective: To ascertain the severity of IDD in some rural communities in upper east of Ghana and to urge the establishment of intervention and control measres for IDD. Subjects and study design: A total of 1061 subjects, made up of about an equal number of children (8-14 years) and women of childbearing age (15-45 years) from seven Sekoti villages and five Builsa villages of the upper east of Ghana were examined for goitre by the palpation method. In addition, every tenth subject examined, provided urine for urinary iodine determination. Results: 68.8% of the subjects had goitre; 9.9% had visible goitre. The goitre rates of the children from Builsa (77.2%) were significantly higher than those from Sekoti (59.1%) [z=4.5; p<0.001]. The overall prevalence of goitre and visible goire in women in the two areas were 70.8% and 15.4% respectively. The women of Sekoti had more goitres (76.6%) but less visible goitres (8.8%) than those of Builsa (63.5% and 21.9%) [p<0.001). The median urinary iodine level for the two survey areas was 1.6 μg/dl. 72% of subjects and urinary iodine less 2 μg/dl/ 24% had urinary iodine levels in the range 2-5 μg/dl and the remainder had urine iodine in the range 5-10 μg/dl. Conclusions: These findings indicate severe IDD in Sekoti and Builsa areas requiring urgent action. Further studies are indicated to determine the cause(s) of the IDD endemia.Item Further studies on the pharmacokinetics of perhexiline maleate in humans(Xenobiotica, 1986) Amoah, A.G.; Gould, B.J.; Parke, D.V.; Lockhart, J.D.F.1. We have performed single-dose pharmacokinetic studies on perhexiline in eight young volunteers, each given 300 mg of Pexid orally, using an h.p.l.c. method for the separation and quantification of the drug and its monohydroxy metabolites in plasma and urine. 2. The plasma concentration of the cis-monohydroxyperhexiline (peak of 473 ± 43 ng/ml at 7.5 ± 2.0 h) was always higher than for unchanged perhexiline (peak of 112 ± 20 ng/ml at 6.5 ± 2.0 h) whereas the concentration of the transmetabolite was either low or undetectable in plasma. These findings indicate the occurrence of stereospecific pre-systemic metabolism of perhexiline which reduces the bioavailability of the parent drug. The plasma elimination half-life of perhexiline was 12.4 ± 6.1 h (range 7-23 h) while that for cis-monohydroxyperhexiline was 19.9 ± 7.7 h (range 10-29 h). 3. Not more than 0.3% of unchanged perhexiline was excreted in the urine over five days in eight subjects. Between 3 and 23% of the orally administered drug was excreted as the cis- or trans-monohydroxy metabolites, the ratio of trans to cis metabolites being 0.52 ± 0.20.Item Single-dose pharmacokinetics of perhexiline administered orally to humans(Journal of Chromatography, 1984) Amoah, A.G.; Gould, B.J.; Parke, D.V.A high-performance liquid chromatographic method for the simultaneous determination of perhexiline and its major metabolites, the cis- and trans-monohydroxyperhexilines M1 and M3, respectively, in human plasma or urine has been developed. Perhexiline and its metabolites are extracted from plasma or urine and derivatized with 1-fluoro-2,4-dinitrobenzene. The extracted dinitrophenyl derivatives of drug and metabolites are separated on a Spherisorb S5 ODS column by gradient elution. The limits of detection for perhexiline and its monohydroxy metabolites were 15 and 3 ng/ml, respectively. The inter-assay coefficients of variation for 100 ng/ml perhexiline, 100 ng/ml M1 and 400 ng/ml M3 were 10.5, 7.6 and 5.6%, respectively (n = 9). The method has been employed in a limited kinetic study with five healthy adult male volunteers who received 150-mg and 300-mg Pexid tablets at an interval of one week. In four subjects perhexiline exhibited marked first pass effects, with plasma M1 levels higher than unchanged perhexiline; in the urine M1 was the predominant metabolite except in one subject who had higher M3 than M1 in the 300-mg Pexid study. The fifth subject exhibited a defective capacity to hydroxylate perhexiline; M1 and M3 were not detectable in plasma, and the urinary excretion of the monohydroxyperhexilines was relatively less, with M3 present in higher amounts than M1.Item Primary paranasal aspergillus granuloma in Saudi Arabia(Tropical and Geographical Medicine, 1988) Dawlatly, E.E.; Anim, J.T.; Sowayan, S.; El-Hassan, A.Y.No abstract availableItem Angiomyolipoma of the nasal cavity(Journal of Laryngology and Otology, 1988) Dawlatly, E.E.; Anim, J.T.; El-Hassan, A.Y.Vascular tumours of the nasal cavity are uncommon and are either hamartomas or true neoplasms, mostly benign. We present an unusual case of angiomyolipoma of the nasal cavity. This harmartomatous lesion is often described in the kidney and may be associated with tuberous sclerosis. To our knowledge, there is no previous report of the lesion in the nasal cavity, and no association with tuberous sclerosis has been demonstrated in this case.Item Local iatrogenic complications in nasopharyngeal rhinoscleroma(Journal of Laryngology and Otology, 1988) Dawlatly, E.E.; Anim, J.T.; Baraka, M.E.The possible role of surgical manipulation in inducing local spread and cicatricial complications in rhinoscleroma is illustrated by the three cases discussed in this paper. This is especially so where its occasional presentation as polypoid lesions of the lower respiratory tract may mimic other more sinister lesions and lead to unwarranted invasive procedures by the unsuspecting clinician. The infective nature of the lesions must be appreciated and confirmed microbiologically for appropriate drug treatment to be used. The benefits of minimal surgical intervention are illustrated in the third case.Item Hidden foreign body as a cause of recurrent hemoptysis(Annals of Saudi Medicine, 1991) Anim, J.T.; Tamimi, T.M.No abstract availableItem Fistula-in-ano: A pathological study(Annals of Saudi Medicine, 1991) Anim, J.T.; Sowayan, S.A.; Grant, C.S.; Al-Breiki, H.A review of 229 cass of fistula-in-ano in our institution has shown that nonspecific inflammatory tissue lines the majority of tracts. Epithelial lining was present in 50 cases and was encountered proportionately more frequently in subjects under 10 years of age, thus supporting a congenital origin as well as infection of anal glands, earlier proposed by other workers. Intestinal contents may have a role in the foreign body response seen in many cases. Locally endemic infectious conditions do not appear to play a significant role in the cause of the disease.Item Breast cancer as seen in King Fahd University Hospital, Al-Khobar, 1983-1986(Journal of the Royal College of Surgeons of Edinburgh, 1989) Anim, J.T.; Sohaibani, M.O.; Grant, C.S.; Tamimi, D.No abstract available]Item Hyperplastic, premalignant and malignant lesions of the prostate gland(Annals of Saudi Medicine, 1999-07) Anim, J.T.; Sathar, S.A.; Bhatti, M.E.No abstract available
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