Research Articles

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A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community

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Now showing 1 - 6 of 6
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    Anaesthesia for caesarean section in haemoglobin SC disease complicated by eclampsia: A case report
    (British Journal of Anaesthesia, 1973-07) Edwards, R.
    Patients with haemoglobin SC discase rarely manifest serious clinical symptoms except during pregnancy when eclampsia and crisis commonly occur. Such a patient, who developed eclampsia which was treated with chlormethiazole infusion, and who subsequently underwent Caesarean section under general anaesthesia, is described. This case confirms previous experience that careful attention to detail with a straightforward technique is the most important factor for a successful outcome.
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    Clinical significance of thiopentone binding to haemoglobin and plasma protein
    (British Journal of Anaesthesia, 1973-08) Edwards, R.; Ellis, F.R.
    The minimum dose of thiopentone required to induce anaesthesia was determined bygiving thiopentone incrementally until verbal counting and eyelash reflexes wereabolished. Males required 2.75 mg/kg (±0.11 SE) and females 2.16 mg/kg ( + 0.10 SE)to abolish verbal counting. Thiopentone requirement correlated positively with haemo-globin concentration (P<0.001) but not with plasma albumin, Ol globulin, total globulinor A/G ratio. The presence of sickle-cell haemoglobins did not influence thiopentonerequirements. It is suggested that this result may have clinical importance
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    A study of body temperatures of anaesthetized man in the tropics
    (British Journal of Anaesthesia, 1977-11) Ellis, F.R.; Zwana, S.L.V.
    Body core and skin temperatures were measured in 20 African patients undergoing herniorrhaphy in hot and humid conditions; one half of the patients received halothane and the other half received diethyl ether. No difference was found between these two groups. Body core temperatures decreased even with an ambient temperature of 28.7°C and a relative humidity of 72% and all sites reached a new thermal equilibrium at 30 min. It is suggested that the level of the re-established thermal equilibrium is a function of the skin to ambient thermal gradient, which depends on the failure of the countercurrent heat exchange mechanism as a result of redistribution of peripheral blood flow. © 1977 Copyright: Macmillan Journals Ltd.
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    The endomorphism ring of pointed separable torsion-free Abelian groups
    (Journal of Algebra, 1978-12) Webb, M.C.
    This paper studies the endomorphism rings of separable torsion-free Abelian groups. Baer [l] defined an Abelian group to be separable if given any finite subset of the group there is a complctcly dccomposablc direct summand of the group containing that subset. The endomorphism rings of such groups have attracted the attention of several workers, notably that of Liebert [7] who characterized those rings isomorphic to the endomorphism ring of some separable Abelian p-group. Moreover, Baer [2] and Kaplansky [6] proved that if two torsion Abelian groups have isomorphic endomorphism rings, then the groups themselves are isomorphic. Results corresponding to these have been proven for homogeneous torsion- free Abelian groups, with Metelli and Salce [8] obtaining a characterization of the endomorphism rings of those groups and Hauptfleisch [5] showing that if two such groups have isomorphic endomorphism rings, then they are almost isomorphic. The meaning of “almost” becomes clear in Theorem 3, from which Hauptfleisch’s result follows as a corollary. We consider only torsion-free Abelian groups and any undefined concepts are standard ones from Fuchs [3]. We define a group to be pointed if the set of types of its rank-l summands contains a unique minimal type, when WC say that the group is pointed in that type. We say a group is idempointed if it is pointed in an idempotent type. Clearly homogeneous separable groups are pointed since all elements of the group have the same type and the group has at least one rank-l summand. We characterize the rings isomorphic to the endomorphism ring of some
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    Survival of burkitt's lymphoma patients in Ghana
    (British Journal of Cancer, 1971) Wosornu, J.L.; Nkrumah, F.K.; Perkins, I.V.
    Of 141 suspected cases of Burkitt's lymphoma referred from all over Ghana between November 1965 and June 30, 1969, the diagnosis of Burkitt's lymphoma was confirmed histologically in 60. This report deals with survival of all 50 treated and evaluable cases. The overall estimated long term survival rate was 38·5% calculated actuarially. It was 63·2% for Stage I (10 of 18); 20·0% for Stage II (2 of 10); and 25·4% for Stages III and IV combined (3 of 22), thus confirming the value of staging as a rough guide to prognosis. Six Stage I patients who died all had large tumors. These results have been compared with a similar study by Morrow et al. (1967) from Uganda.
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    Tumour site and renal dysfunction as factors influencing leucopenia after chemotherapy for Burkitt's lymphoma.
    (British Journal of Cancer, 1979) Biggar, R.J.; Nkrumah, F.K.
    Forty-four (44) patients with Burkitt's lymphoma received identical combination chemotherapy on the basis of body surface area. Patients with renal dysfunction, more common in those with abdominal tumours, were at significantly greater risk of developing severe leucopenia (less than 1000 cells/dl) than those with normal renal function (P less than 0.0001). Similar results were seen in a series of 8 patients with normal marrows treated with only i.v. cyclophosphamide and intrathecal methotrexate. Giving a lower initial dose of cyclophosphamide seemed to reduce the risk of severe leucopenia in 5 additional patients with evidence of renal dysfunction. The mechanism is postulated as delayed excretion of the active metabolites of cyclophosphamide. Adjustment of the chemotherapeutic dose should be considered when treating patients with renal dysfunction.