Research Articles
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A research article reports the results of original research, assesses its contribution to the body of knowledge in a given area, and is published in a peer-reviewed scholarly journal. The faculty publications through published and on-going articles/researches are captured in this community
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Item Anaphylatoxin (AT) induced increased vascular permeability in mouse pinna and the effect of non steroidal antiinflammatory drugs(West African Journal of Pharmacology and Drug Research, 1977) Sackeyfio, A.C.; Yamyolia, AItem Proceedings: Histopathological effects of anaphylatoxin in the guinea pig(West African Journal of Pharmacology and Drug Research, 1975) Sackeyfio, A.C.Item Definition of the histaminic component of the bronchoconstrictor and cardiovascular effects of anaphylatoxin in the guinea-pig(British Journal of Pharmacology, 1971) Sackeyfio, A.C.Item Anaphylatoxin-induced release of a substance with prostaglandin-like activity in isolated perfused guinea-pig lungs(British Journal of Pharmacology, 1972) Sackeyfio, A.C.Item Anaphylatoxin(at) induced release of rabbit aorta contracting substance (RCS) in isolated perfused guinea pig lungs(West African Journal of Pharmacology and Drug Research, 1976) Sackeyfio, A.C.Item A comparison of the histopathological effects of anaphylatoxin (AT) and prostaglandins E2 (PGE2) and F(2α) (PGF(2α)) in guinea pig lungs(British Journal of Pharmacology, 1975) Sackeyfio, A.C.Item The nature of adrenergic mechanisms involved in anaphylatoxin activity in the guinea-pig(British Journal of Pharmacology, 1972) Hicks, R; Sackeyfio, A.C.1. Evidence is presented to elucidate the nature of the adrenergic mechanisms involved in responses of the guinea-pig to anaphylatoxin (AT). 2. Investigation by means of adrenalectomy, adrenergic neurone blockade, α- and β- adrenoceptor blockade and exclusion of autonomic reflexes, revealed that the adrenergic mechanisms provoked included catecholamine release from the adrenal medulla, sympathetic reflex activity, stimulation of adrenergic neurones and α- and β-adrenoceptor activity. 3. The cardiovascular effects of AT, mediated by histamine release, were largely attributable to adrenal medullary and adrenergic neuronal mechanisms. These mechanisms also exerted a restraint on the predominantly histamine mediated bronchoconstrictor effect of AT. 4. The cardiovascular effects of AT activity, not attributable to histamine release, were also probably associated with catecholamine release. However, the bronchoconstrictor component of this AT activity was not significantly affected by guanethidine, and it would, therefore, appear that neuronal bronchodilator mechanisms did not exert a restraint upon this aspect of AT activity. 5. These findings are generally compatible with previous work showing that adrenergic mechanisms operate during AT-induced responses. In contrast to previous reports, however, the adrenergic activity was predominantly associated with the effects of released histamine.Item An interaction between exogenously administered anaphylatoxin and histamine in the guinea-pig(Archives Internationales De Pharmacodynamie Et De Therapie, 1972) Hicks, R; Sackeyfio, A.C.