Browsing by Author "Yang, T."
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Item Association between Posttraumatic Stress Disorder and Pre-flood Behavioral characteristics among Children Aged 7-15 years in Hunan, China(2011) Peng, M.; Liu, A.; Zhou, J.; Wen, S.; Li, S.; Yang, T.; Li, X.; Huang, X.; Abuaku, B.; Tan, H.Objective: To explore the relationship between posttraumatic stress disorder (PTSD) and preflood behavioral characteristics among children aged 7–15 years in Hunan, China. Subjects and Methods: In 2000, a retrospective study was carried out among children who had been exposed to the 1998 floods in Hunan. A multistage sampling method was used to select subjects from the flood-affected areas. A structured questionnaire administered to the children selected was used to diagnose PTSD based on the DSM-IV criteria. A parent questionnaire was used to measure preflood behavioral characteristics related to health, behavioral, and habit problems. The association between PTSD and preflood behavioral characteristics was assessed using χ2-tests and multivariate logistic regression. Results: A total of 7,038 children from 13,450 households, aged 7–15 years, were investigated. The overall prevalence of PTSD was 2.05%. Generally, the PTSD-positive rate increased with increasing scores for behavioral characteristics. Conclusion: Preflood behavioral characteristics are an important factor influencing the prevalence of PTSD among children exposed to floods. It is therefore necessary to give special attention to children with behavioral problems in order to reduce the psychological impact of floods.Item Evidence for an Adult-Like Type 1-Immunity Phenotype of Vδ1, Vδ2 and Vδ3 T Cells in Ghanaian Children With Repeated Exposure to Malaria(Frontier, 2022) León-Lara, X.; Yang, T.; Fichtner, A.S.; Bruni, E.; von Kaisenberg, C.; Eiz-Vesper, B.; Dodoo, D.; Adu, B.; Ravens, S.Effector capabilities of γδ T cells are evident in Plasmodium infection in young and adult individuals, while children are the most vulnerable groups affected by malaria. Here, we aimed to investigate the age-dependent phenotypic composition of Vδ1+, Vδ2+, and Vδ3+ T cells in children living in endemic malaria areas and how this differs between children that will develop symptomatic and asymptomatic Plasmodium falciparum infections. Flow cytometric profiling of naïve and effector peripheral blood γδ T cells was performed in 6 neonates, 10 adults, and 52 children. The study population of young children, living in the same malaria endemic region of Ghana, was monitored for symptomatic vs asymptomatic malaria development for up to 42 weeks after peripheral blood sampling at baseline. For the Vδ2+ T cell population, there was evidence for an established type 1 effector phenotype, characterized by CD94 and CD16 expression, as early as 1 year of life. This was similar among children diagnosed with symptomatic or asymptomatic malaria. In contrast, the proportion of type 2- and type 3-like Vδ2 T cells declined during early childhood. Furthermore, for Vδ1+ and Vδ3+ T cells, similar phenotypes of naïve (CD27+) and type 1 effector (CD16+) cells were observed, while the proportion of CD16+ Vδ1+ T cells was highest in children with asymptomatic malaria. In summary, we give evidence for an established adult-like γδ T cell compartment in early childhood with similar biology of Vδ1+ and Vδ3+ T cells. Moreover, the data supports the idea that type 1 effector Vδ1+ T cells mediate the acquisition of and can potentially serve as biomarker for natural immunity to P. falciparum infections in young individuals from malaria-endemic settings.Item Morbidity and mortality among populations suffering floods in Hunan, China: the role of socioeconomic status(Journal of Food, Risk and Management, 2009) Abuaku, B.K.; Zhou, J.; Li, X.; Li, S.; Li, X.; Liu, A.; Yang, T.; Tan, H.A cross-sectional survey in randomly selected eight counties affected by the 1998 floods in Hunan, China, was conducted in year 2000 using a structured questionnaire. Data obtained included demographic and housing characteristics of subjects; family income; morbidity and mortality during and after the floods; and type and severity of flood suffered. Gender, age group, source of drinking water, type of flood suffered, and severity of flood suffered played highly significant roles in morbidity while gender, age group, educational level, family size, and type of flood suffered played highly significant roles in mortality among populations suffering floods. Intervention strategies in such populations need to take into account these characteristics with the view of reducing the health impact of floods.