Browsing by Author "Wilson, J.B."
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Item Birthweight distribution at Korle-Bu Teaching Hospital, Ghana(East African Medical Journal, 2001-08) Klufio, C.A.; Lassey, A.T.; Annan, B.D.; Wilson, J.B.Objectives: To determine the birthweight distribution of singleton births at the Korle-Bu Teaching Hospital and to determine if selected socio-demographic and reproductive characteristics that are known to be associated with birthweight would show the association in our setting. Design: A non-randomised cross-sectional survey of all deliveries within the study period. Setting: Korle-Bu Teaching Hospital, a tertiary institution, delivering about 11,000 women a year. Study population: From 1st November to 12th December 1994, 866 singleton normally formed livebirths and fresh stillbirths were sequentially enrolled. Data sources: Data sources were the antenatal and delivery records of the subjects and an interviewer-administered questionnaire. Results: The mean birthweight for the total sample was 3070g ± 616g. One hundred and fifteen (13.3%) babies were low birthweight The mean birthweight for those with reliable dates and born at term was 3262g ± 488.8g. Multiple logistic regression analysis showed lack of antenatal malaria chemoprophylaxis and a history of previous low birthweight to be significantly associated with low birthweight. Conclusion: Although the mean birthweight of Korle-Bu babies was lower than those of US A and UK babies, it was comparable with those from other developing countries. Antenatal malaria chemoprophylaxis is a practical intervention that can produce an increase in mean birthweight and reduce the risk of low birthweight in our population.Item A double-blind placebo controlled randomised trial of misoprostol and oxytocin in the management of the third stage of labour(British Journal of Obstetrics and Gynaecology, 2000-09) Walley, R.L.; Wilson, J.B.; Crane, J.M.G.; Matthews, K.; Sawyer, E.; Hutchens, D.Objective: To compare oral misoprostol 400 μg with intramuscular oxytocin 10 IU in the routine management of the third stage. Design: Double-blind placebo controlled trial. Setting: Main referral hospital and its associated polyclinics in Accra, Ghana. Population: Four hundred and one low risk women, in the second stage of labour with anticipated vaginal delivery, who entered labour spontaneously. Methods: After delivery of the anterior shoulder of the baby, the women were randomised to receive either: 1. misoprostol 400 μg powder in water orally and 1 mL normal saline intramuscular injection (placebo); or 2. powdered cellulose in water orally (placebo) and 1 mL oxytocin 10 IU intramuscular injection. Main outcome measures: Change in haemoglobin concentration from before delivery to 12 hours postpartum. Secondary outcomes included need for additional oxytocics, blood loss > 500 mL and > 1000 mL, operative intervention for postpartum haemorrhage, and side effects, including nausea, vomiting, diarrhoea, shivering and elevated temperature. Results: Demographic characteristics were similar. There was no significant difference in change in haemoglobin concentration between the two groups (0.60 g/dL for misoprostol and 0.55 g/dL for oxytocin; relative difference 9.6%; 95% CI 20.5-39.6%; P = 0.54). There were no significant differences in secondary outcomes with the exception of shivering, which occurred more frequently in the misoprostol group (22.2% vs 5.7%; relative risk 4.73; 95% CI 2.31-9.68; P < 0.0001). Conclusions: In low risk women oral misoprostol appears to be as effective in minimising blood loss in the third stage of labour as intramuscular oxytocin. Shivering was noted more frequently with misoprostol use, but no other side effects were noted. Misoprostol has great potential for use in the third stage of labour especially in developing countries.Item The Ghana - Carnegie Postgraduate Program in Obstetrics & Gynaecology(Ghana Medical Journal, 1999-03) Adadevoh, S.W.K.; Martey, J.O.; Wilson, J.B.; Collison, A.H.K.The Carnegie Corporation of New York, the American College of Obstetricians and Gynaecologists (ACOG). USA. the Royal College of Obstetricians and Gynaecologists (RCOG) UK. the Ghana Ministry of Health. University of Ghana Medical School. Accra and the University of Science and Technology School of Medical Sciences. Kumasi. collaborated to establish an innovative community-oriented Postgraduate Training Program in Obstetrics and Gynecology in 1987 (PIG Obgyn). In the 10 years since its inception (1987- 1997), 14 specialists graduated This paper outlines the Aims and Objectives of the Program. the various components of Reproductive Health where most research and publications were done. and the important role that professional training can play in reproductive health research