Browsing by Author "Seshi, M."
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Item Prevalence and impact of hepatitis B and C virus co-infections in antiretroviral treatment naïve patients with HIV infection at a major treatment center in Ghana(Journal of Medical Virology, 2012-01) Sagoe, K.W.C.; Agyei, A.A.; Ziga, F.; Lartey, M.; Adiku, T.K.; Seshi, M.; Arens, M.Q.; Mingle, J.A.A.Data on the effects of the presence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients co-infected with these viruses and HIV in West Africa are conflicting and little information is available in Ghana. A cohort of 138 treatment naïve individuals infected with HIV was screened for HBV and HCV serologic markers; HBsAg positive patients were tested for HBeAg, anti-HBe, and anti-HBc IgM. The viral load of HIV-1 in the plasma was determined in 81 patients. Eighteen of the 138 patients (13%) and 5 (3.6%) had HBsAg and anti-HCV, respectively. None of the patients had anti-HBc IgM, but 10 (55.6%) and 8 (44.4%) of the 18 patients who were HBsAg positive had HBeAg and anti-HBe, respectively. In patients with measurement of CD4 + undertaken within 1 month (n=83), CD4 + count was significantly lower in patients with HBeAg (median [IQR], 81 [22-144]) as compared to those with anti-HBe (median [IQR], 210 [197-222]) (P=0.002, CI: -96.46 to 51.21). However, those with HIV mono-infection had similar CD4 + counts (median [IQR], 57 [14-159]) compared to those with HBeAg (P=1.0, CI: -71.75 to 73.66). Similar results were obtained if CD4 + count was measured within 2 months prior to initiation of HAART (n=119). Generally, HBV and anti-HCV did not affect CD4 + and viral loads of HIV-1 in plasma but patients with HIV and HBV co-infection who had HBeAg had more severe immune suppression as compared to those with anti-HBe. This may have implication for initiating HAART in HBV endemic areas. © 2011 Wiley Periodicals, Inc.