Browsing by Author "Seidu, I."
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Item Analysis of Exchange Rates as Time-Inhomogeneous Markov Chain with Finite States(Journal of Applied Mathematics, 2022) Mettle, F.O.; Boateng, L.P.; Quaye, E.N.B.; Aidoo, E.K.; Seidu, I.Irrespective of whether the test for homogeneity is significant or not, most researchers assume time-homogeneity in analysing Markov chains due to scanty literature on the analysis of time-inhomogeneous Markov chains. Based on the assumption that, for each point in time in the future, a stochastic process will be subjected to a randomly selected transition matrix from an ergodic set of transition matrices the process was subjected to in the recent past, a methodology was proposed for analysing the long-run behaviours of time-inhomogeneous Markov chains. The proposed model was implemented to historical data consisting of the exchange rate of cedi-dollar, cedi-pound, and cedi-euro spanning over 6 years (January 2012 to December 2017). The results show that under certain “closeness” conditions, the long-run behaviours of the time-inhomogeneous case are almost identical to those of the time-homogeneous case. The paper asserted that even if the Markov chain exhibit time-inhomogeneity, analysing the Markov chain under the assumption of time-homogeneity is a step in the right direction under certain “closeness” conditions; otherwise, the proposed method is recommended. It was also found that investing in dollars yields better returns than the other currencies in Ghana.Item Assessing the Relationship between Individual Level Dietary Intake and the Occurrence of Preeclampsia/Eclampsia and Haemorrhage among Pregnant Women in Eastern Region of Ghana: A Prospective Cohort Study(Texila International Journal of Public Health, 2023) Avoka, J.A.; Ohemeng, A.; Seidu, I.; et al.Pre-eclampsia/eclampsia (PE-E) and haemorrhage are dangerous diseases that occur in pregnancy. This study seeks to assess the relationship between individual-level dietary intake and the occurrence of pre-eclampsia/eclampsia and haemorrhage among pregnant women in the Eastern Region of Ghana. The prospective cohort study involved all pregnant women in their third trimester of pregnancy (>28 weeks gestational age) reporting for antenatal care (ANC) in seven Hospitals in the Eastern Region of Ghana. The study used a 24-hour repeated dietary recall to elicit dietary intake information from pregnant women until delivery. The majority of pregnant women in this study had adequate consumption of phosphorus far above the RDI, coupled with an inadequate intake of calcium, excess intake of sodium, and manganese. The average dietary intake for carbohydrates in this study was rather higher than the RDA. There was a statistically significant association between PE-E and the intake of vitamin C. A statistically significant association exists between the intake of calcium and vitamin A and haemorrhage. The findings show that pregnant women who consumed adequate and excess amounts of vitamin C reduced their odds of developing PE-E by 41.7% and 39.8%, respectively. The results show that pregnant women who had an excess intake of calcium were 6.128 times the odds of developing haemorrhage compared to those who had inadequate intake. Again, pregnant women who had adequate intake of vitamin A were 4.351 times the odds of developing haemorrhage compared to those who had inadequate intake. It is recommended that more nutrition specialists to be trained and posted to counsel pregnant women on nutrition in pregnancy to avert the consequences of PE-E and haemorrhage.Item Current Realities of Wilms Tumor Burden and Therapy in Ghana(Journal of Pediatric Surgery, 2024) Kontchou, N-A.T.; Amankwah, E.; Seidu, I.; et al.Background: Between 2005 and 2014, Ghana's Wilms tumor (WT) 2-year disease-free survival of 44% trailed behind that of high-income countries. This study aimed to uncover social determinants of health leading to preventable WT death in Ghana. Methods: WT patient records (2014e2022) at Korle-Bu Teaching Hospital (KBTH; Ghana) were reviewed retrospectively. Demographics, clinical course, tumor characteristics, and survival were evaluated using t-tests, Pearson Chi-square, and multivariate Cox logistic regression. Results: Of 127 patients identified, 65 were female. Median age was 44 months [IQR 25e66]. Forty-eight patients (38%) presented with distant metastasis (75% lung, 25% liver), which associated with hypo albuminemia (p ¼ 0.009), caregiver informal employment (p ¼ 0.04), and larger tumors (p ¼ 0.002). Despite neoadjuvant chemotherapy shrinking 84% of tumors, larger initial size associated with incom plete resection (p ¼ 0.046). Of 110 nephrectomies, 31 patients had residual disease, negatively impacting survival (p ¼ 2.7 10 5 ). Twenty-two patients (17%) abandoned treatment (45% before nephrectomy; 55% after nephrectomy), with seven patients ultimately lost to follow-up (LTFU). Decedents represented 43% of stage IV patients compared to 28% in other stages. Event-free survival (EFS) was 60% at 4 years with overall survival (OS) at 67%. Conclusions: Although Ghana's WT survival has improved, informal employment and distance from KBTH predisposed patients to delayed referral, greater tumor burden, hypoalbuminemia, and lower survival. Type of Study: Prognosis Study. Level of Evidence: IIItem Maternal and neonatal characteristics that influence very early neonatal mortality in the Eastern Regional Hospital of Ghana, Koforidua: a retrospective review(BMC Research Notes, 2018-02) Avoka, J.A.; Adanu, R.M.K.; Wombeogo, M.; Seidu, I.; Dun-Dery, E.J.Objective This study was conducted to determine the maternal and neonatal characteristics that influence very early neonatal mortality using 811 delivery records at the Eastern Regional Hospital of Ghana. Results The very early neonatal mortality rate was 9 per 1000 live births. Multi-parity reduced the odds of very early neonatal death by 30%. Mothers with a previous neonatal death had about 8 times the odds of having a very early neonatal death as compared to those without a history of neonatal death.Item Time series analysis of the relationship between diarrhea in children and Rota 2 vaccine in the Fanteakwa District of the eastern region of Ghana(BMC Pediatrics, 2021) Avoka, J.A.; Dun-Dery, E.J.; Seidu, I.; Abou, A.N.E.; Twene, P.; Tandoh, I.O.; Dun-Dery, F.Background: Rotavirus is considered the main causal factor of severe gastroenteritis among infants and children globally. The association with severe rotavirus infection is mostly worse among the least developed countries, mainly due to inadequate access to medical care and poverty. This study was conducted to determine the seasonal effects in respect of diarrhea cases in children, the association between diarrhea cases and Rota2 vaccine in the Fanteakwa District of the Eastern Region of Ghana. Methods: The study compares monthly diarrhea cases against children vaccinated with Rota2 extracted from DHIM S2 spanning May 2012 to December 2017 in Fanteakwa District. A univariate association between diarrhea cases and children vaccinated with Rota 2 was conducted using the R-software version 3.4.4 with the use of forecast, tseries and TSAPred. Pearson Correlation coefficient was also computed between monthly diarrhea cases and Rota 2 as well as lagged values of Rota 2 and Diarrhea cases. Results: The study shows that February recorded the highest average number of diarrhea cases (172) over the period 2012 to 2017 with a standard deviation of 59. However, a one-way analysis of variance shows a significant difference amongst the monthly averages with an F-statistic of 0.042 and P-value of 0.064. It is observed that the correlations between each of the Rota2 doses and the lagged cases are positive, showing higher Rota2 doses a month ago ((Xt − 1),0.346 to 0.735), two months ago ((Xt − 2),0.383 to 0.746), three months ago ((Xt − 3), 0.330 to 0.737) and four months ago ((Xt − 4), 0.236 to 0.723) are associated with lower diarrhea cases. The results also show that an increase in the previous two month’s Rota2 figures by 100 is associated with a significant decrease in the currently expected diarrhea cases by approximately 36. Conclusion: Seasonal variations exist in the occurrence of diarrhea in children, with January recording the highest number of diarrhea cases (172). There is a relationship between episodes of diarrhea in children and Rota2 (pvalue = 0.064); thus, the more children are vaccinated with Rota2, the less diarrhea cases are recorded. Diarrhea cases in Fanteakwa district are generally low, except 2013 and 2016 where the cases are higher than the rest of the other years.