Browsing by Author "Sasu, C."
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Item Quinine Sulphate Microparticles as Treatment for Leishmaniasis(Journal of Tropical Medicine, 2020-04-30) Allotey-Babington, G.L.; Amponsah, S.K.; Nettey, T.; Sasu, C.; Nettey, H.Background. Leishmaniasis is a neglected tropical disease caused by the Leishmania parasite and transmitted by the female phlebotomine sandfly. +e disease can affect the skin (least fatal) or internal organs (most fatal). Current treatment options for leishmaniasis have a number of adverse effects, and there appears to be resistance by the protozoan parasite (Leishmania spp.). Reports suggest that quinine sulphate, not indicated for leishmaniasis, is effective in killing the Leishmania parasite. Indeed, the efficacy of any drug is dependent on the concentration at the target site, which is also almost dependent on drug formulation. +e current study assessed the pharmacokinetic profile of the microparticulate formulation of quinine sulphate and its in vitro and in vivo efficacy against Leishmania donovani. Methods. Quinine sulphate was encapsulated in bovine serum albumin by the spraydrying method. Quinine sulphate microparticles were evaluated for size, zeta potential, drug content, encapsulation efficiency, and in vitro release properties. Afterwards, the pharmacokinetic characteristics of quinine sulphate microparticles were estimated and in vivo efficacy studies were also conducted. Results. +e size range of the quinine sulphate microparticles was between 2.0 and 5.0 μm. Microparticles had an average zeta potential of −35.2mV and an encapsulation efficiency of 94.5%. Also, Cmax, t1/2, and AUC were all significantly desirable for quinine sulphate microparticles compared to the drug powder. Quinine sulphate microparticles significantly reduced parasite load in rat organs than amphotericin B. Conclusion. Overall, quinine sulphate microparticles had better pharmacokinetic profile and showed higher efficacy against Leishmania donovani parasites in vivo. +us, quinine sulphate microparticles have the potential, especially, in treating visceral leishmaniasisItem Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats(International Journal of Green Pharmacy; 8(4):271-275., 2014) Adjei, S.; Amoateng, P.; Osei-Safo, D.; Sasu, C.; N'guessan, B.B.; Addo, P.; Asiedu-Gyekye, J.I.Synedrella nodiflora (L) Gaertn (family Asteraceae) is traditionally used in Ghana for the management of epilepsy, hiccup and threatened abortion. The anticonvulsant and other related neuro-pharmacological effects of a hydro-ethanolic extract in murine models have been established. To this end, we evaluated a sub-acute toxicity of the hydro-ethanolic whole plant extract in rats. The effects of a continuous 14-day oral administration of the extract (100, 300 and 1000 mg/kg) on haematological and serum biochemical parameters were measured. The extract produced no mortality in the rats treated during the study period. The extract also did not significantly affect any of the haematological and serum biochemical indices measured. This result suggests that a 14-day oral administration of the hydro-ethanolic extract of Synedrella nodiflora is relatively safe in Sprague-Dawley male rats under the present laboratory conditions.