Browsing by Author "Ndiaye, M."
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Item Analysis of Genotype-Environment Interaction and Yield Stability of Introduced Upland Rice in the Groundnut Basin Agroclimatic Zone of Senegal(Hindawi, 2021) Kanfany, G.; Ayenan, M.A.T.; Zoclanclounon, Y.A.B.; Kane, T.; Ndiaye, M.; Diatta, C.; Diatta, J.; Gueye, T.; Fofana, A.Item Genetic diversity of polymorphic vaccine candidate antigens (apical membrane antigen-1, merozoite surface protein-3, and erythrocyte binding antigen-175) in Plasmodium falciparum isolates from Western and Central Africa(American Journal of Tropical Medicine and Hygiene, 2011-02) Soulama, I.; Bigoga, J.D.; Ndiaye, M.; Bougouma, E.C.; Quagraine, J.; Casimiro, P.N.; Stedman, T.T.; Sirima, S.B.The malaria vaccine candidate antigens erythrocyte binding antigen 175 (EBA-175), merozoite surface protein 3 (MSP-3), and apical membrane antigen (AMA-1) from Plasmodium falciparum isolates from countries in central and west Africa were assessed for allelic diversity. Samples were collected on filter paper from 600 P. falciparum-infected symptomatic patients in Cameroon, Republic of Congo, Burkina Faso, Ghana, and Senegal and screened for classspecific amplification fragments. Genetic diversity, assessed by mean heterozygosity, was comparable among countries. We detected a clinical increase in eba 175 F-allele frequency from west to east across the study region. No statistical difference in msp-3 allele distribution between countries was observed. The ama-1 3D7 alleles were present at a lower frequency in central Africa than in West Africa. We also detected little to no genetic differentiation among sampling locations. This finding indicates that, at least at the level of resolution offered by restriction fragment length polymorphism analysis, these antigens showed remarkable genetic homogeneity throughout the region sampled, perhaps caused by balancing selection to maintain a diverse array of antigen haplotyes. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.Item Pharmacovigilance of malaria intermittent preventive treatment in infants coupled with routine immunizations in 6 african countries(Journal of Infectious Diseases, 2012) De Sousa, A.; Rabarijaona, L.P.; Tenkorang, O.; Inkoom, E.; Ravelomanantena, H.V.; Njarasoa, S.; Whang, J.N.; Ndiaye, J.L.; Ndiaye, Y.; Ndiaye, M.; Sow, D.; Akadiri, G.; Hassan, J.; Dicko, A.; Sagara, I.; Kubalalika, P.; Mathanga, D.; Bizuneh, K.; Randriasamimanana, J.R.; Recht, J.; Bjelic, I.; Dodoo, A.BACKGROUND: Intermittent preventive treatment in infants (IPTi) is a new malaria control strategy coupled with the delivery of routine immunizations recommended by the World Health Organization since 2009 for countries with moderate to high endemicity. To evaluate its safety profile and identify potential new adverse events (AEs) following simultaneous administration of sulfadoxine-pyrimethamine (SP-IPTi) with immunizations, we measured AE incidence and evaluated spontaneous AE reporting. METHODS: A cohort event monitoring study was conducted on 24 000 infants in 2 countries after administration of SP-IPTi during routine immunizations. Additional pharmacovigilance training and supervision were conducted to stimulate AE passive reporting in 6 African countries. RESULTS: No serious AEs were found by active follow-up, representing 95% probability that the rate does not exceed 1 per 8000. No serious AEs were found by retrospective review of hospital registers. The rate of moderate AEs probably linked to immunization and/or SP-IPTi was 1.8 per 1000 doses (95% confidence interval, 1.50-2.00). Spontaneous reporting of AEs remained <1% of cases collected by active follow-up. CONCLUSIONS: Simultaneous administration of SP-IPTi and immunizations is a safe strategy for implementation with a low risk of serious AEs to infants. Strategies toward strengthening spontaneous reporting in Africa should include not only the provider but also beneficiaries or their caregivers.