Browsing by Author "Mohammed, J."
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Item Klebsiella pneumoniae ST147 harboring blaNDM-1, multidrug resistance and hypervirulence plasmids(Microbiology Spectrum, 2024) Ofosu-Appiah, F.; Acquah, E.E.; Mohammed, J.; et al.The spread of hypervirulent (hv) and carbapenem-/multidrug-resistant Klebsiella pneumoniae is an emerging problem in healthcare settings. The New Delhi metallo-β-lactamase-1 (blaNDM-1) is found in Enterobacteriaceae including K. pneumo niae. The blaNDM-1 is capable of hydrolyzing β-lactam antibiotics which are used for treatment of severe infections caused by multidrug-resistant Gram-negative bacteria. This is associated with the unacceptably high mortality rate in immunocompromised burn injury patients. This study reports on the characterization of blaNDM-1 gene and virulence factors in hv carbapenem-/multidrug-resistant K. pneumoniae ST147 in the burns unit of a tertiary teaching hospital during routine surveillance. Two K. pneumoniae strains were obtained from wounds of burn-infected patients from May 2020 to July 2021. The hypervirulence genes and genetic context of the blaNDM-1 gene and mobile genetic elements potentially involved in the transposition of the gene were analyzed. We identified a conserved genetic background and an IS26 and open reading frame flanking the blaNDM-1 gene that could suggest its involvement in the mobilization of the gene. The plasmid harbored additional antibiotic resistance predicted regions that were responsible for resistance to almost all the routinely used antibiotics. To ensure the identification of potential outbreak strains during routine surveillance, investigations on resistance genes and their environment in relation to evolution are necessary for molecular epidemiology.Item The impact of trade on environmental quality and sustainable development in Ghana(World Development Sustainability, 2024) Kindo, M.D.; Adams, A.A.; Mohammed, J.Since gaining independence in 1957, Ghana has significantly increased its economic ties with the global community through trade liberalization policies. However, this integration has profoundly affected the environment, particularly in utilizing natural resources, and has subsequently impacted sustainable development. This study examines the relationship between trade, environmental considerations, and sustainable development within the Ghanaian context. Using the autoregressive distributed lag (ARDL) error correction estimation technique, we found that trade positively impacts sustainable development in Ghana despite causing adverse environmental effects. This suggests that economic gains are prioritized over environmental preservation, indicating weak sustainability. However, sustainable development requires a balance between economic, social, and environmental factors, and a shift towards strong sustainability may be necessary for long-term sustainability. Therefore, pivotal policy interventions are warranted to navigate the path toward strong sustainability. Mechanisms that ensure the judicious pricing of Ghana’s forest and natural resources are necessary to optimize resource exploitation while mitigating negative externalities. Ghana can promote inclusive and sustainable development by establishing a delicate balance between economic expansion and environmental stewardship.