Browsing by Author "McKinney, D.M."
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Item A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults(Vaccine Journal, 2009) Newman, M.J.; Jin, X.; De-Rosa, S.; Cooper, C.; Thomas, E.; Keefer, M.; Fuchs, J.; Blattner, W.; Livingston, B.D.; McKinney, D.M.; Noonan, E.; Decamp, A.; Defawe, O.D.; Wecker, M.A Phase I human vaccine trial of a novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was conducted in 84 healthy adult volunteers. The vaccine immunogenicity was assessed by an intracellular cytokine staining assay for IL-2, IL-4, TNF-alpha and IFN-gamma. Sixty eight percent (32/47) of subjects had a positive CD4+ T response after receiving two vaccinations of the polypeptide vaccine. The responding CD4+ T cells made various combinations of IL-2, IL-4, IFN-gamma, and TNF-alpha. The study demonstrated that the EP-1043 vaccine is safe, well-tolerated, and immunogenic.