Browsing by Author "Liu, W."
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Item Aflatoxin–albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult ghanaian population(Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2009-01) Tang, L.; Xu, L.; Afriyie-Gyawu, E.; Liu, W.; Wang, P.; Tang, Y.; Wang, Z.; Ankrah, N.A.; Huebner, H.J.; Ofori-Adjei, D.et.alA study of aflatoxin (AF) exposure and the levels of vitamins A and E was carried out with a group of 507 Ghanaian participants. AFB1–albumin adducts (AFB-AA) were measured by radioimmunoassay and vitamins A and E were measured by high-performance liquid chromatography (HPLC). The average level of serum AFB-AA was 0.94 ± 0.64 (range = 0.1–4.44) pmol mg−1 albumin. Mean levels of vitamins A and E were 1.32 ± 0.48 (range = 0.41–4.85) µmol l−1 and 15.68 ± 4.12 (range = 6.35–30.40) µmol l−1, respectively. A significantly negative correlation was found between serum AFB-AA and vitamin A levels (r = −0.110, p = 0.013). An even stronger, significant negative, correlation was found between serum AFB-AA and vitamin E levels (r = −0.149, p < 0.001). Serum AFB-AA levels were statistically higher (median = 0.985 pmol mg−1 albumin) in subjects who had low levels of both vitamins A and E as compared with the levels (median = 0.741 pmol mg−1 albumin) subjects who had high vitamins A and E levels (p trend = 0.001). To verify these findings, blood samples were again collected from 165 of the 507 people 3 months after the initial collection. Significantly negative correlations were confirmed between levels of serum AFB-AA and both vitamins A (r = −0.232, p = 0.003) and E (r = −0.178, p = 0.023). Again, high serum AFB-AA concentrations (median = 1.578 pmol mg−1 albumin) were found in subjects with low levels of vitamins A and E compared with the concentrations (median = 1.381 pmol mg−1 albumin) in subjects with high levels of vitamins A and E (p trend = 0.002). These data show that AF exposure was associated with decreased levels of serum vitamins A and E in high-risk human populations, which may significantly influence the incidence of AF-related adverse health effects. © 2009 Taylor & Francis Group, LLC.Item Prevalence and risk factors for childhood obesity in Changsha and Shenzhen in China(Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2010) Li, X.; Liao, B.; Liu, J.; Tan, H.; Huang, W.; Benjamin, A.; Liu, W.; Huang, X.; Wen, S.Objective: To determine the prevalence and the risk factors for childhood obesity in Changsha and Shenzhen, China. Methods: A case-control study was conducted in 209 obese children (the cases) identified in the investigation on childhood obesity in 6 288 children aged 6 to 9 years in Changsha and Shenzhen in China and 209 children with normal weight (the controls). The cases and controls were matched by gender, age, and school. Adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the risk factors were measured. Results: The prevalence rate of overweight and obese children was 9.28% and 3.30% in Changsha, and 12.17% and 4.22% in Shenzhen, respectively. The rate of overweight children is significantly higher in Shenzhen than in Changsha. No statistical difference was observed in the rate of obesity between the children in both cities. Paternal obesity (OR 1.78, 95% CI 1.01 to 3.16), maternal weight gain during pregnancy>or=15.0 kg (OR 5.22, 95% CI 2.78 to 9.80), birth weight>or=4.00 kg (OR 2.55, 95% CI 1.24 to 5.26), unhealthy snacks>or=1 per week (OR 3.94, 95% CI 1.11 to 13.99), and watching television>or=2 hours per day(OR 2.35, 95% CI 1.01 to 5.47) were associated with childhood obesity when potential confounding factors were adjusted by multi-variable logistic regression analysis. Conclusion: Paternal obesity, gestational weight gain, high birth weight, and unhealthy life-style are important risk factors for obesity in urban children in south China.