Browsing by Author "Lee, K.D."
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Item Anti-melanoma, tyrosinase inhibitory and anti-microbial activities of gold nanoparticles synthesized from aqueous leaf extracts of teraxacum officinale(International Journal of Cosmetic Science, 2012) Tettey, C.O.; Nagajyothi, P.C.; Lee, S.E.; Ocloo, A.; Minh An, T.N.; Sreekanth, T.V.M.; Lee, K.D.There has been a tenacious search for pharmaceuticals of natural origin, as they are cost-effective and are noted for having little or no side effects. The rate at which diseases are developing resistance to synthetic drugs is quite alarming, and the side effects of these drugs remain an excruciating agony to the pharmaceutical industry. Gold nanoparticles (AuNPs) have wide applications in current technology. However, their use in medicine has not been adequately explored. Chemical methods for the synthesis are associated with environmental benignity and tissue toxicity on in vivo administration. For the first time, we have synthesized AuNPs from leaf extracts of Teraxacum officinale that were found to have significant anti-melanoma, tyrosinase inhibitory and anti-microbial effects, and hence stand as promising candidates for use in cosmetics medical and food industries.Item Antioxidant activity of solvent fractions of taraxacum officinale (dandelion) leaves(Journal of Herbs, Spices and Medicinal Plants, 2014-05) Tettey, C.O.; Ocloo, A.; Nagajyothi, P.C.; Lee, K.D.Methanolic crude extract of dandelion (Taraxacum officinale) leaves was fractionated in solvents and antioxidant activity evaluated. The ethyl acetate and butanol fractions showed high antioxidant activities in all the assays. Methylene chloride and water fractions demonstrated moderate activity, whereas the hexane fraction had relatively lower activity. Copyright © Taylor & Francis Group, LLC.Item An in vitro analysis of antiproliferative and antimicrobial activities of solvent fractions of Taraxacum officinale (Dandelion) leaf(Journal of Applied Pharmaceutical Science, 2014-04) Tettey, C.O.; Ocloo, A.; Nagajyothi, P.C.N.; Lee, K.D.The persistent upsurge in multidrug resistance of common pathogens and global increase in the incidence of noninfectious diseases such as cancers and diabetes has led to an urgent need for the discovery of novel and affordable pharmaceuticals. Taraxacum officinale commonly called dandelion has been used in traditional medicine for the treatment of various conditions. Although the antimicrobial and antiproliferative properties of various crude extracts of T. officinale have been reported, there is little report on the antimicrobial and antiproliferative activities of its solvent fractions. In this study, various solvent fractions from the crude methanolic extract of T. officinale leaves were examined for their antiproliferative and antimicrobial activities with the aim of providing a baseline data for the discovery of the antiproliferative and antimicrobial phytocompounds in T. officinale leaves. Whereas, methylene chloride fraction showed the highest antiproferative activity, inhibiting 97 % proliferation of SGT oral cancer cells the butanol fraction showed the highest antimicrobial activity in both disc diffusion and broth dilution assays. Therefore the methylene chloride and the butanolic fractions could respectively act as leads for the discovery of important anticancer and antimicrobial phytocompounds from T. officinale. © 2014 C.O. Tettey et al.