Browsing by Author "Brown, R.H."
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Item The impact of maternal adverse childhood experiences and prenatal depressive symptoms on foetal attachment: Preliminary evidence from expectant mothers across eight middle-income countries(Journal of Affective Disorders, 2021) Brown, R.H.; Eisner, M.; Osafo, J.; et al.Background: Mothers from middle-income countries (MIC) are estimated to have higher rates of adverse child hood experiences (ACEs) and depression during pregnancy compared to mothers from high income countries. Prenatal depression can adversely impact on a mother’s feelings towards her foetus and thus may be partially responsible for intergenerational transmission of risk associated with maternal ACEs. However, the extent to which prenatal depressive symptoms mediate the association between maternal ACEs and foetal attachment is unknown. Methods: Data on foetal attachment, ACEs, and prenatal depression came from mothers in their third trimester of pregnancy (n = 1,185) located across eight MICs, participating in the prospective birth cohort Evidence for Better Lives Study – Foundational Research (EBLS-FR). Data were from the baseline measurement. Results: Full-sample path mediation analyses, adjusting for relevant covariates, suggested a full mediating effect of prenatal depression. However, at the individual-country level, both positive and negative effects of ACEs on foetal attachment were observed after the inclusion of depressive symptoms as a mediator, suggesting cultural and geographical factors may influence a mother’s empathic development after ACE exposure. Limitations: As no follow-up measurements of depressive symptoms or postnatal attachment were included in the analyses, the findings cannot be extrapolated to the postnatal period and beyond. Further, causality cannot be inferred as the study was observational. Conclusions: The findings reinforce the importance of screening for prenatal depression during antenatal care in MICs. Addressing prenatal depression within maternal health care may support foetal attachment and contribute to reducing the intergenerational transmission of disadvantage.Item What Research Questions Should the Next Generation of Birth Cohort Studies Address? An International Delphi Study of Experts(Academic Pediatricsv, 2020-04-06) Osafo, J.; Brown, R.H.; Eisner, M.; Valdebenito, S.; Walker, S.; Tomlinson, M.; Hughes, C.; Ward, C.L.; Sikander, S.; Fearon, P.; Dunne, M.P.; Madrid, B.; Baban, A.; Thang, V.V.; Fernando, A.D.; Murray, A.L.OBJECTIVE: Birth cohort studies (BCS) have generated a wealth of invaluable basic scientific and policy-relevant information on a wide range of issues in child health and development. This study sought to explore what research questions are currently a priority for the next generation of BCS using a 3- round Delphi survey of interdisciplinary experts. METHODS: Twenty-four (Round I, N = 17; Round II, N = 21; Round III, N = 18) experts across a wide range of fields (eg, psychology, public health, and maternal/child health) agreed to participate. In Round I, the expert panel was invited to freely respond to the question, “what are the key scientific questions future birth cohort studies should address?” Content analysis of answers was used to identify 47 questions for rating on perceived importance by the panel in Round II and consensus- achieving questions were identified. Questions that did not reach consensus in Round II were posed again for expert rerating in Round III. RESULTS: Twenty six of 47 questions reached consensus in Round II, with an additional 6 reaching consensus in Round III. Consensus-achieving questions rated highly on importance spanned a number of topics, including environmental effects on child development, intergenerational transmission of disadvantage, and designing BCS to inform intervention strategies. CONCLUSION: Investigating the effects of family/environmental factors and social disadvantage on a child’s development should be prioritized in designing future BCS. The panel also recommended that future BCS are designed to inform intervention strategies.