Browsing by Author "Arora, R."

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    Emerging OP354-Like P[8] Rotaviruses Have Rapidly Dispersed from Asia to Other Continents
    (Molecular Biology and Evolution, 2015-08) Zeller, M.; Heylen, E.; Damanka, S.; Pietsch, C.; Donato, C.; Tamura, T.; Kulkarni, R.; Arora, R.; Cunliffe, N.; Maunula, L.; Potgieter, C.; Tamim, S.; De Coster, S.; Zhirakovskaya, E.; Bdour, S.; O'Shea, H.; Kirkwood, C.D.; Seheri, M.; Nyaga, M.M.; Mphahlele, J.; Chitambar, S.D.; Dagan, R.; Armah, G.; Tikunova, N.; Van Ranst, M.; Matthijnssens, J.
    The majority of human group A rotaviruses possess the P[8] VP4 genotype. Recently, a genetically distinct subtype of the P[8] genotype, also known as OP354-like P[8] or lineage P[8]-4, emerged in several countries. However, it is unclear for how long the OP354-like P[8] gene has been circulating in humans and how it has spread. In a global collaborative effort 98 (near-)complete OP354-like P[8] VP4 sequences were obtained and used for phylogeographic analysis to determine the viral migration patterns. During the sampling period, 1988–2012, we found that South and East Asia acted as a source from which strains with the OP354-like P[8] gene were seeded to Africa, Europe, and North America. The time to the most recent common ancestor (TMRCA) of all OP354-like P[8] genes was estimated at 1987. However, most OP354-like P[8] strains were found in three main clusters with TMRCAs estimated between 1996 and 2001. The VP7 gene segment of OP354-like P[8] strains showed evidence of frequent reassortment, even in localized epidemics, suggesting that OP354like P[8] genes behave in a similar manner on the evolutionary level as other P[8] subtypes. The results of this study suggest that OP354-like P[8] strains have been able to disperse globally in a relatively short time period. This, in combination with a relatively large genetic distance to other P[8] subtypes, might result in a lower vaccine effectiveness, underscoring the need for a continued surveillance of OP354-like P[8] strains, especially in countries where rotavirus vaccination programs are in place.