Browsing by Author "Addo, H.A."
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Item Allergic characteristics of urban schoolchildren with atopic eczema in Ghana(Journal of the European Academy of Dermatology and Venereology, 2010-04) Hogewoning, A.A.; Larbi, I.A.; Addo, H.A.; Amoah, A.S.; Boakye, D.; Hartgers, F.; Yazdanbakhsh, M.; Van Ree, R.; Bouwes Bavinck, J.N.; Lavrijsen, A.P.M.Background: Atopic eczema is an increasing clinical problem in Africa. Objective: To determine allergic characteristics and to identify possible risk factors for eczema among schoolchildren in an urbanized area in Ghana. Patients and methods: Schoolchildren aged 3-16 years with eczema were recruited. For each patient, one to three age- and sex-matched controls were selected. All children completed a questionnaire and were skin prick tested with a panel of allergens. Blood was drawn to determine the total and allergen-specific IgE. Conditional logistic regression models with the matching factors included in the model were used to calculate the odds ratios and to adjust for possible confounders. Results: A total of 52 children with eczema (27 boys and 25 girls) and 99 controls were included. Levels of total IgE were found to be 9.1 (1.1; 78.4) times more often elevated in children with eczema. This association was mainly driven by elevated IgE levels against cockroach antigen. Children with eczema were found to have 2.0 (0.87; 4.7) times more often positive skin prick tests (SPT), but this association diminished to 1.2 (0.40; 3.6) after adjustment for total IgE levels. Frequent washing with soap was identified as a risk factor for the development of eczema among these children. Conclusion: Schoolchildren with eczema in Ghana were characterized by elevated IgE levels especially against cockroach antigen. The association between eczema and positive SPT was much weaker suggesting immune hyporesponsiveness of the skin. After adjustment for IgE level, SPT were less suitable to distinguish children with and without eczema. © 2010 European Academy of Dermatology and Venereology.Item A Clinical Study of Hydroquinone Reaction in Skin Bleaching in Ghana(Ghana Medical Journal, 1992) Addo, H.A.A clinical study was conducted among 35 subjects who were seen at the Dermatology Out-patient Clinic at Korle-Bu Teaching Hospital. Accra. with adverse skin reactions following the use of topical bleaching agents. Hydroquinone-containing preparations were found to be the most commonly used agents. Ochronosis and colloid millia were the main clinical findings and their distribution suggested a photocontact reaction.Item Mycobacterium Ulcerans Infection (Buruli Ulcer) in the Ga District of the Greater Accra Region.(Ghana Medical Journal, 1995) Addo, H.A.A study of 22 subjects affected by Mycobaaerium ulcuans (Buruli Ulcer) in the Ga District of Greater Accra Region of Ghana. bordering the rivers Densu and Nsaki is presented. of these subjects 68.2% were less than 15 years of age with a male to female ratio of t .8: 1 and 63.6% were either pre-school or school children. 72.7% of the subjects were first affected before the age of 10 years. The distribution of the skin lesions involved the exposed skin areas in 86.4% of cases and contact cases were identified in 50% of the subjects. A complication of squamous cell carcinoma was observed in one subject. The possible modes of transmission arc discussedItem Pyoderma Gangrenosum and Inflammatory Bowel Disease- Case Reports(Ghana Medical Journal, 2005-12) Nkrumah, K.N.; Addo, H.A.; Tachi, K.Two cases of ulcerative colitis preceded by pyoderma gangrenosum in two female patients are described. One patient developed leg ulcers, pre-sumed to be due to sickle cell disease; the other developed crops of ulcers all over the body for several years. These patients attended and were managed at the Medical and the Reconstructive Surgical Units of the Korle Bu Teaching Hospital. The unusual presentation of pyoderma gangreno-sum and the importance of diagnosing underlying probable inflammatory bowel disease is high-lighted.Item Squamous cell carcinoma associated with prolonged bleaching(Ghana Medical Journal, 2000-09) Addo, H.A.Squamous cell carcinoma related to cumulative exposure to ultraviolet radiation is common in Caucasians but rare in blacks. Continuous skin bleaching results in the loss of melanin pigmentation. A case of squamous cell carcinoma with pulmonary metastasis is presented in an adult Ghanaian female who earlier in life indulged in skin bleaching with hydroquinone predominantly for more than 20 years.