Reduced Health-Related Quality of Life in Patients With Systemic Sclerosis: A Cross-Sectional Analysis of PROMIS Global Health Data From the International COVAD-2 e-Survey.

Abstract

Systemic sclerosis (SSc) is a multisystem disorder characterized by autoimmunity, fibrosis of the skin and internal organs, and vascu lopathy [1–3]. SSc is associated with altered physical function, pain, and psychological consequences including depression and anxiety [4–7], leading to impaired health-related quality of life (HRQoL) [8]. However, there remains an unmet need for a thorough eval uation of the HRQoL status and its determinants in SSc patients. Patient-Reported Outcomes Measurement Information System (PROMIS) is a set of person-centered measures that evaluate and monitor physical, mental, and social health in individuals living with or without chronic conditions [9]. As for HRQoL, PROMIS global physical health (GPH) and global mental health (GMH) scores have demonstrated favorable reliability in evaluating physical and mental health [10]. In this study, we investigated PROMIS GMH and GPH scores in a global cohort of patients with SSc compared to those with non-SSc autoimmune inflammatory rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and individuals without autoimmune diseases using PROMIS global health data obtained through the second COVID-19 vaccination in autoimmune disease (COVAD-2) survey.