dc.contributor.author | Newman, M. J. | |
dc.contributor.author | Gorse, G. J. | |
dc.contributor.author | Baden, L. R. | |
dc.contributor.author | Wecker, M. | |
dc.contributor.author | Newman, M. J. | |
dc.contributor.author | Ferrari, G. | |
dc.contributor.author | Weinhold, K. J. | |
dc.contributor.author | Livingston, B. D. | |
dc.contributor.author | Villafana, T. L. | |
dc.contributor.author | Li, H. | |
dc.contributor.author | Noonan, E. | |
dc.contributor.author | Russell, N. D. | |
dc.date.accessioned | 2012-04-30T14:38:21Z | |
dc.date.accessioned | 2017-10-19T12:08:03Z | |
dc.date.available | 2012-04-30T14:38:21Z | |
dc.date.available | 2017-10-19T12:08:03Z | |
dc.date.issued | 2008 | |
dc.identifier.uri | http://197.255.68.203/handle/123456789/846 | |
dc.description.abstract | We evaluated EP HIV-1090 vaccine, a DNA plasmid encoding 21 cytotoxic T-lymphocyte (CTL) epitopes of human immunodeficiency virus type 1 (HIV-1) and the pan-DR helper T-lymphocyte epitope (PADRE), in a dose escalation, randomized, double-blinded, placebo-controlled Phase 1 trial. Vaccine, at 0.5, 2.0, or 4.0mg doses, or placebo was injected four times over 6 months. Forty-two healthy, HIV-1-uninfected adults were enrolled. Using an interferon-gamma ELISPOT assay, a response to PADRE was detected in one vaccine recipient. Three vaccine recipients raised anti-HIV-1 CD8+ CTL measured by chromium-release assay. The vaccine was safe and well-tolerated, but only weakly immunogenic. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Vaccine Journal 26(2): 215-23 | en_US |
dc.title | Safety and immunogenicity of cytotoxic T-lymphocyte poly-epitope, DNA plasmid (EP HIV-1090) vaccine in healthy, human immunodeficiency virus type 1 (HIV-1)-uninfected adults | en_US |
dc.type | Article | en_US |
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