Abstract:
The impact of malaria on global health has continually prompted the need to develop
more e ective diagnostic strategies that could overcome deficiencies in accurate and early detection.
In this review, we examine the various biosensor-based methods for malaria diagnostic biomarkers,
namely; Plasmodium falciparum histidine-rich protein 2 (PfHRP-2), parasite lactate dehydrogenase
(pLDH), aldolase, glutamate dehydrogenase (GDH), and the biocrystal hemozoin. The models that
demonstrate a potential for field application have been discussed, looking at the fabrication and
analytical performance characteristics, including (but not exclusively limited to): response time,
sensitivity, detection limit, linear range, and storage stability, which are first summarized in a tabular
form and then described in detail. The conclusion summarizes the state-of-the-art technologies
applied in the field, the current challenges and the emerging prospects for malaria biosensors
