Kemp, K.Akanmori, B.D.Kurtzhals, J.A.L.Adabayeri, V.Goka, B.Q.Hviid, L.2019-03-042019-03-042002-11Vol. 24(11-12): pp 545-8DOI: 10.1046/j.1365-3024.2002.00599.xhttp://ugspace.ug.edu.gh/handle/123456789/28489P. falciparum malaria is associated with increased activation among peripheral lymphocytes. In the present study, we investigated markers of susceptibility to apoptosis and expression of IFN-γ and IL-4 by CD28- and CD28+ T cells in West African children with acute P. falciparum malaria. The study showed increased susceptibility to apoptosis and cytokine production among T lymphocytes during acute malaria but also that T cells, in particular IFN-γ producing CD28- T cells, were substantially reduced. These results are in line with previous studies suggesting that certain T cell subsets are sequestered away from the peripheral blood during P. falciparum malaria.enApoptosisCD28CytokinesMalariaT-cellsArticle