Ding, P.Chen, D.Bastow, K.F.Nyarko, A.K.Wang, X.Lee, K.2013-06-152017-10-162013-06-152017-10-162004Ding, P., Chen, D., Bastow, K.F., Nyarko, A.K., Wang, X., & Lee, K. (2004). Cytotoxic isoprenylated flavonoids from the roots of sophora flavescens. Helvetica Chimica Acta, 87(10), 2574-2580.http://197.255.68.203/handle/123456789/3221Three new flavonoids, which are isoprenylated by fused 2,2-dimethyl-3,4-dihydro-2H-pyran moieties, were isolated from the roots of Sophora flavescens and named flavenochromanes A–C (1–3). Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Flavenochromane C (3) showed strong cytotoxic activity against A549 (lung carcinoma), 1A9 (ovarian carcinoma), KB (epidermoid carcinoma of the nasopharynx), and KB-Vin (drug-resistant variant KB) cell lines with IC50 values ≤1.7 μM, and significant activity against the MCF-7 (breast adenocarcinoma) cell line with an IC50 value of 3.6 μM. Flavenochromane B (2) displayed slightly lower inhibitory effects (IC50 3.2–6.9 μM) as compared with 3.enArticle