Akpalu, J.Atiase, Y.Yorke, E.Fiscian, H.Kootin-Sanwu, C.Akpalu, A.2019-11-182019-11-182017-03http://dx.doi.org/10.4314/gmj.v51i1.8http://www.ghanamedj.org/articles/March2017/Final%20Myxoedema%20Coma.pdfhttp://ugspace.ug.edu.gh/handle/123456789/33629Journal ArticleMyxoedema coma is a rare life-threatening disease, and it is essential that it is managed appropriately to reduce the associated high mortality. However, in the setting where efficient healthcare delivery is hampered by inadequacies, the management of such cases may pose a significant challenge. We present the case of a middle-aged woman diagnosed with myxoedema coma and severe hyponatremia. The case report highlights some of the challenges that may be encountered during the management of myxoedema coma in similar settings and outlines the management strategies undertaken to overcome them in the absence of national guidelines. It also brings to the fore the need for clinicians to look out for clinical features suggestive of hypothyroidism particularly among high risk individuals for early diagnosis and treatment.enmyxoedema comamanagementchallengesGhanaArticle