Adjei, S.Amoateng, P.Osei-Safo, D.Ahedor, B.N’guessan, B.B.Addo, P.Asiedu-Gyekye, I.J.2015-06-252017-10-142015-06-252017-10-142014http://197.255.68.203/handle/123456789/6336Synedrella nodiflora (L) Gaertn (family Asteraceae), a common weed in Ghana, is traditionally used for the management of epilepsy, hiccup and threatened abortion. To further promote the ethno-pharmacological uses of the plant, an acute toxicity of a hydro-ethanolic whole plant extract was assessed in male Sprague-Dawley rats. The lethal dose (LD50) and effects of a single oral admin-istration of the extract (1600, 3200 and 6400 mg kg-1) on haematological and serum biochemical parameters were measured. The extract produced no mortality in the rats treated during a 48-hour examination and after a subsequent 12-day assessment. Thus the LD50 was indicated as being greater than 6400 mg kg-1. The extract also did not significantly affect any of the haematological and serum biochemical indices. This result suggests that acute oral administration of the hydro-ethanolic extract of Synedrella nodiflora is virtually non-toxic in male Sprague-Dawley rats under normal laboratory conditions.Synedrella nodifloraacute toxicitySprague-Dawley ratshaematologybiochemical analysisArticle